Publications by authors named "Nelly Akhmatova"
Article Synopsis
- The study investigates how one or two doses of inactivated adjuvanted influenza vaccines affect immune responses, specifically focusing on the expression of endosomal Toll-like receptors (TLRs) in patients with common variable immunodeficiency (CVID).
- Six CVID patients received one vaccine dose followed by nine patients who received two doses; flow cytometry was used to analyze immune cell populations and TLR expression.
- Findings show that while key lymphocyte populations remained stable post-vaccination, patients receiving two doses exhibited increased TLR3 and TLR9 expression, indicating that two-dose vaccine regimens may enhance immune responses in CVID patients.
Expression of Toll-like Receptors on the Immune Cells in Patients with Common Variable Immune Deficiency after Different Schemes of Influenza Vaccination.
Viruses
October 2023
Background: for the first time, the effect of one and two doses of adjuvanted influenza vaccines on toll-like receptors (TLRs) in patients with common variable immunodeficiency (CVID) was studied and compared (primary vaccination with one vs. two doses, primary vs. repeated vaccination).
View Article and Find Full Text PDFBackground: Influenza prophylaxis with the use of quadrivalent vaccines (QIV) is increasingly being introduced into healthcare practice.
Methods: In total, 32 healthy adults and 6 patients with common variable immunodeficiency (CVID) received adjuvant QIV during 2018-2019 influenza season. Depending on initial antibody titers, healthy volunteers were divided into seronegative (≤1:20) and seropositive (≥1:40).
Background: Rehabilitation therapy in children with neuromotor development disorders can be carried out with the use of various methods.
Objectives: The aim of this study was to determine the efficiency of rehabilitation carried out with the use of the new therapeutic method MNRI (Masgutova Neurosensorimotor Reflex Integration) in children with cerebral palsy (CP) by objective measurements with a brainstem auditory evoked potentials (BAEP) examination.
Material And Methods: Besides the known parameters, Interpeak Latency I-V (IPL I-V) in BAEP, an original parameter proposed by Pilecki was introduced, called a relative IPL I-V value.
Programmed cell death (PCD) is a fundamental process regulating immune homeostasis. During acute viral infections PCD of lymphocytes by apoptosis is necessary for removing the excess of activated antigen-reactive T cells and down-regulation of the immune response. On the other hand, apoptosis is the key mechanism of elimination of viral-infected cells.
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