Overexpression of the gene in the frontal cortex of mice causes sex-dependent changes in learning, attention, and anxiety-like behavior.

Apolipoprotein E (ApoE) is a protein that is important for lipid storage, transport, and metabolism. gene variants are associated with Alzheimer's disease, as well as attentional function in healthy humans. Previous research has shown that transcription is increased following stimulation of the pathway between the locus coeruleus (LC) and frontal cortex (FC) in mice.

Overexpression of the gene in the frontal cortex of mice causes sex-dependent changes in learning, attention, and anxiety-like behavior.

Apolipoprotein E (ApoE) is a protein that is important for lipid storage, transport, and metabolism. gene variants are associated with Alzheimer's disease (AD), as well as attentional function in healthy humans. Previous research has shown that transcription is increased following stimulation of the pathway between the locus coeruleus (LC) and frontal cortex (FC) in mice.