Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an study.

Objectives: In this study, we investigated the potential of amoxicillin-loaded polymeric microspheres to be delivered to tooth root infection sites via a bioactive reparative cement.

Materials And Methods: Amoxicillin-loaded microspheres were synthesized by a spray-dray method and incorporated at 2.5% and 5% into a mineral trioxide aggregate cement clinically used to induce a mineralized barrier at the root tip of young permanent teeth with incomplete root development and necrotic pulp.

Influence of the addition of microsphere load amoxicillin in the physical, chemical and biological properties of an experimental endodontic sealer.

Aim: To develop an endodontic sealer with amoxicillin-loaded microsphere and to evaluate its properties.

Methods: Experimental sealer was obtained by mixing 70wt% UDMA, 15wt% GDMA and 15wt% BISEMA. In addition, CQ, DHEPT and PB were incorporated at 1 mol% and 0.