Publications by authors named "Nelia Jimenez-Alduan"
Article Synopsis
- Exposure of calreticulin (CALR) on the surface of stressed and dying cells is crucial for their effective uptake by antigen-presenting cells like dendritic cells, aiding in the adaptive immune response and memory formation.
- In contrast, the presence of phosphatidylserine (PS) signals tolerogenic macrophages for quick engulfment of dying cells, highlighting different immune responses.
- The article outlines a protocol for using flow cytometry to measure CALR and PS on plasma cells in multiple myeloma patients, and suggests this method can be adapted for use with other cancers as well.
A better understanding of multiple myeloma (MM) biology has led to the development of novel therapies. However, MM is still an incurable disease and new pharmacological strategies are needed. Dinaciclib, a multiple cyclin-dependent kinase (CDK) inhibitor, which inhibits CDK1, 2, 5 and 9, displays significant antimyeloma activity as found in phase II clinical trials.
View Article and Find Full Text PDFImmunogenic cell death (ICD) has been proposed to be a crucial process for antitumor immunosurveillance. ICD is characterized by the exposure and emission of Damage Associated Molecular Patterns (DAMP), including calreticulin (CRT). A positive correlation between CRT exposure or total expression and improved anticancer immunosurveillance has been found in certain cancers, usually accompanied by favorable patient prognosis.
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