genotype is associated with cirrhosis or transition to cirrhosis in treatment-naive patients with chronic HCV genotype 1 infection: the international observational Gen-C study.

Background And Purpose: Contradictory data exist on the association between host interleukin-28B () rs12979860 genotype and liver fibrosis in patients with chronic hepatitis C (CHC). This large, international, observational study (NCT01675427/MV25600) investigated relationships between rs12979860 genotype and liver fibrosis stage in CHC patients.

Methods: A total of 3003 adult, treatment-naive CHC patients were enrolled into the study.