Understanding Host-Virus Interactions: Assessment of Innate Immune Responses in Cells after Arenavirus Infection.

is the natural host of various arenaviruses, including the human-pathogenic Lassa virus. Homologous arenaviruses, defined here as those having as a natural host, can establish long-lasting infection in while these animals rapidly clear arenaviruses having another rodent species as a natural host (heterologous viruses). Little is known about the mechanisms behind the underlying arenavirus-host barriers.