Publications by authors named "Nelci Antunes de Moura"
Article Synopsis
- Capsaicin (CAP), the compound that gives chili peppers their heat, has potential health benefits, but its safety and effectiveness against cancer development are not fully understood.
- This study investigated the effects of dietary CAP on urothelial lesions caused by the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in male rats, involving six different treatment groups.
- Results showed that rats consuming 0.02% CAP alongside BBN had a significant reduction in cancerous lesions and related biological markers, indicating that dietary CAP is both safe and may help protect against cancer development.
Colorectal cancer is the third most diagnosed cancer worldwide and linked to dietary/lifestyle factors. ( (AP) contains bioactive compounds with beneficial effects /. We evaluated the effects of AP feeding against 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis.
View Article and Find Full Text PDFCapsaicin (CPS, 8-methyl-N-vanillyl-trans-6-nonenamide), a pungent alkaloid from chili peppers, has contradictory effects in both experimental and human carcinogenesis. Thus, we evaluated the modifying effects of chronic CPS during the promotion and progression stages of rat colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH). Male Wistar rats were given four subcutaneous injections of DMH (40 mg/body weight (b.
View Article and Find Full Text PDFArticle Synopsis
- Capsaicin, the compound that makes chili peppers spicy, has shown mixed results regarding its potential to cause cancer, with some studies indicating it might help prevent cancer while others suggest possible risks at high doses.
- The study evaluated the effects of capsaicin on colon cancer induced by DMH in male Wistar rats, finding that capsaicin promoted anti-cancer effects by influencing genes related to apoptosis and cell differentiation.
- Results indicated that capsaicin reduced the number of abnormal cell formations (ACF) in the colon, suggesting it may help prevent colon cancer, despite no significant differences in tumor occurrence among the tested groups.
The modifying effects of aqueous yacon extract (AYE) and Lactobacillus acidophilus CRL 1014 against colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats were investigated. Animals were allocated into five groups: G1: untreated group; G2: DMH-treated group; G3: DMH+L. acidophilus-treated group; G4: DMH+AYE-treated group; G5: DMH+L.
View Article and Find Full Text PDFThe potential promoting effect of Diuron was investigated in a mouse model of mammary and urinary bladder carcinogenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA) and N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). Four-week old female Swiss mice were allocated to five groups: Groups G1-G3 received DMBA (5 x 1.5 mg/mouse) and BBN (8 x 7.
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