[Risk factors for carbohydrate metabolism disorders from a chronobiological position].

steady increase in the prevalence of carbohydrate metabolism disorders is closely related to overweight and obesity. Obesity is associated with a sedentary lifestyle, poor diet, sleep disturbance, which can lead to dysfunction of circadian rhythms with a decrease in the production of the hormone melatonin. of the study is to clarify the most significant risk factors for carbohydrate metabolism disorders in obese patients from the standpoint of chronobiology.

Disrupted circadian rhythms of body temperature, heart rate and fasting blood glucose in prediabetes and type 2 diabetes mellitus.

We report a progressive disruption of 24-h rhythms in fasting blood glucose (FBG), body temperature (BT) and heart rate (HR) associated with metabolic dysfunction and the development of prediabetes (PD) and type 2 diabetes mellitus (T2DM) in overweight middle-aged (40-69 years old) humans. Increasing BT and HR mean values and declining 24-h BT and HR amplitudes accompany adverse changes in metabolic state. Increased nocturnal BT and a phase delay of the 24-h BT rhythm, deviant 24-h HR profile and a phase advance of the 24-h HR and FBG rhythms are early signs of the PD metabolic state.

[Role of proinflammatory cytokines in the development and progression of micro- and macroangiopathies in patients with type 2 diabetes mellitus].

Diabetes mellitus is a systemic lesion of the micro- and macrocirculatory bed. We examined a total of 110 people with type 2 diabetes mellitus and lesions of the major vessels of the lower limbs. Of these, 70 patients were found to have microangiopathy combined with nephropathy.

[Postoperative recurrence of a nodular goiter].

Long-term results were followed up from 3 to 15 years in 649 patients with different morphological forms of the nodular goiter. Postoperative recurrent nodular goiter was diagnosed in 26.8% of the patients.

[A clinico-pathogenetic assessment of the membrane structure and functions of the peripheral blood lymphocytes in insulin-dependent diabetes mellitus].

The structure and functions of lymphocyte membranes with characterization of their phospholipid composition, lipid peroxidation intensity (LP), activity of membranous ATPases and a type of the immune status were investigated in patients with insulin dependent diabetes mellitus. The results obtained were indicative of considerable differences (LP) in the lymphocytes of these patients as compared to those of healthy controls. LP intensity showed correlation with change in the ratio of phospholipid fractions and change in ATPase activity.