Changes in Digestive Health, Satiety and Overall Well-Being after 14 Days of a Multi-Functional GI Primer Supplement.

A recent review proposed a role for multi-functional food or supplement products in priming the gut to support both digestive and systemic health. Accordingly, we designed and eva-luated the effect of a multi-functional gastrointestinal (GI) primer supplement on participant-reported measures for digestive health, quality-of-life (e.g.

Local and Systemic Effects of Bioactive Food Ingredients: Is There a Role for Functional Foods to Prime the Gut for Resilience?

Scientific advancements in understanding the impact of bioactive components in foods on the gut microbiota and wider physiology create opportunities for designing targeted functional foods. The selection of bioactive ingredients with potential local or systemic effects holds promise for influencing overall well-being. An abundance of studies demonstrate that gut microbiota show compositional changes that correlate age and disease.

[Surgical treatment of patients with chest malignancies in anti-tuberculosis hospital].

Objective: To evaluate the effectiveness of surgical treatment of patients with malignancies of lungs, pleura and chest wall in early and long-term follow-up period in anti-tuberculosis hospital.

Material And Methods: There were 2139 patients between 2016 and 2020. Chest tumors were diagnosed in 290 (13.

Edible Far Eastern Ferns as a Dietary Source of Long-Chain Polyunsaturated Fatty Acids.

Young fronds of ferns are consumed as a vegetable in many countries. The aim of this study was to analyze three fern species that are available for sale in the Russian Far East as dietary sources in terms of fatty acids that are important for human physiology: arachidonic acid (20:4n-6, ARA), eicosapentaenoic acid (20:5n-3, EPA) and other valuable long-chain polyunsaturated fatty acids. The content of ARA and EPA was 5.

Variability of fatty acid profiles in ferns: Relation to fern taxonomy and seasonal development.

Ferns are known to contain long chain polyunsaturated fatty acids which may provide health benefits. The objective of this study was to investigate ferns of Pacific temperate regions (Far East of Russia and New Zealand) as sources of valuable fatty acids: arachidonic (20:4n-6) and eicosapentaenoic (20:5n-3). Fatty acids were analyzed in fronds of 23 fern species from 12 families.

Mitochondrial distribution violation and nuclear indentations in neurons differentiated from iPSCs of Huntington's disease patients.

Huntington's disease (HD) is an inherited disease caused by an expansion of cytosine-adenine-guanine (CAG) repeats in the huntingtin gene () that ultimately leads to neurodegeneration. To study the molecular basis of this disease, induced pluripotent stem cells (iPSCs) generated from patients' fibroblasts were used to investigate axonal mitochondrial trafficking and the nature of nuclear indentations. Pathological and control iPSCs generated from patients with a low number of repeats were differentiated in striatal neurons of the brain.

Patient-Specific iPSC-Based Models of Huntington's Disease as a Tool to Study Store-Operated Calcium Entry Drug Targeting.

Neurodegenerative pathologies are among the most serious and socially significant problems of modern medicine, along with cardiovascular and oncological diseases. Several attempts have been made to prevent neuronal death using novel drugs targeted to the cell calcium signaling machinery, but the lack of adequate models for screening markedly impairs the development of relevant drugs. A potential breakthrough in this field is offered by the models of hereditary neurodegenerative pathologies based on endogenous expression of mutant proteins in neurons differentiated from patient-specific induced pluripotent stem cells (iPSCs).

[The experience of the using Tolperisone in a complex conservative therapy of an osteoarthrosis of a hip joint].

Aim: The comparison of the efficiency of the standard scheme of a conservative medicinal therapy of an OA of a hip joint and the modified scheme (with the muscle relaxant of the central action - Tolperisone) was the research objective.

Material And Methods: The prospective research of the complex conservative therapy of two pools of patients with initial stages of a coxarthrosis from 2014 for 2017 with the subject assessment articulary treatment components is conducted.

Results: As a result of the studying of the clinical performance of the modified scheme in comparison with the standard scheme of the therapy at patients with the prevalence of an arthritic component of a disease established the best results of the therapy.

Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons.

Background: Huntington's disease (HD) is an incurable hereditary neurodegenerative disorder, which manifests itself as a loss of GABAergic medium spiny (GABA MS) neurons in the striatum and caused by an expansion of the CAG repeat in exon 1 of the huntingtin gene. There is no cure for HD, existing pharmaceutical can only relieve its symptoms.

Results: Here, induced pluripotent stem cells were established from patients with low CAG repeat expansion in the huntingtin gene, and were then efficiently differentiated into GABA MS-like neurons (GMSLNs) under defined culture conditions.

Dual polarized receiving steering antenna array for measurement of ultrawideband pulse polarization structure.

To measure simultaneously two orthogonal components of the electromagnetic field of nano- and subnano-second duration, an antenna array has been developed. The antenna elements of the array are the crossed dipoles of dimension 5 × 5 cm. The arms of the dipoles are connected to the active four-pole devices to compensate the frequency response variations of a short dipole in the frequency band ranging from 0.

[Genetic Cell Reprogramming: A New Technology for Basic Research and Applied Usage].

Gene function disclosure and the development of modern technologies of genetic manipulations offered the possibility of genetic reprogramming application to alter cell specialization. With the involvement of a gene set that encodes the transcription factors responsible for the pluripotent state, any cell of an adult body could be reprogrammed into the embryonal.state and pluripotency could be induced in this cell.

Cultivation and differentiation change nuclear localization of chromosome centromeres in human mesenchymal stem cells.

Chromosome arrangement in the interphase nucleus is not accidental. Strong evidences support that nuclear localization is an important mechanism of epigenetic regulation of gene expression. The purpose of this research was to identify differences in the localization of centromeres of chromosomes 6, 12, 18 and X in human mesenchymal stem cells depending on differentiation and cultivating time.

Reactivation of Х chromosome upon reprogramming leads to changes in the replication pattern and 5hmC accumulation.

Once set, the inactive status of the X chromosome in female somatic cells is preserved throughout subsequent cell divisions. The inactive status of the X chromosome is characterized by many features, including late replication. In contrast to induced pluripotent stem cells (iPSCs) in mice, the X chromosome in human female iPSCs usually remains inactive after reprogramming of somatic cells to the pluripotent state, although recent studies point to the possibility of reactivation of the X chromosome.

Late replication of the inactive x chromosome is independent of the compactness of chromosome territory in human pluripotent stem cells.

Dosage compensation of the X chromosomes in mammals is performed via the formation of facultative heterochromatin on extra X chromosomes in female somatic cells. Facultative heterochromatin of the inactivated X (Xi), as well as constitutive heterochromatin, replicates late during the S-phase. It is generally accepted that Xi is always more compact in the interphase nucleus.

[Influence of specialized protein food products on functional status of wrestlers].

Influence of system of protein and amino acid rehabilitation on a functional condition of wrestlers is studied. It is established that the offered system has a wide range of adaptogenic. Found that the proposed system and actoprotective activity shows immunoprotective effect on the humoral immune system, accelerates processes of restoration after physical activity, provides a gain of working capacity, and also promotes adaptation of cardiovascular system for physical exercise.

[Bacteriological tests of the operative material in patients with lung tuberculosis].

64 patients with lung tuberculosis were operated on after chemotherapy course using regimens I and III. 69 patients were operated on after the treatment by DOTS/PLUS protocol. The obtained operative material was bacteriologically tested.

[Bioactive substance used for treatment and preventive maintenance of liver diseases].

In the present article the review of bioactive substances rendering beneficial effect on an organism at diseases of a liver is resulted. Action of such classes of bioactive substances as amino acids and their derivatives, vitamins, macro- and microelements, herbal bioactive substances, cytamins is described. Bioactive substances can be used in manufacture food supplements or foodstuffs of a medical and prophylactic feed.