[Leukocyte function as one of the indices of resistance to influenza in children].

Preliminary results of comparative characterization of the functional activity of leukocytes by cytochemical, virologic, immunologic, and clinical methods of examinations in institutionalized young infants are summarized. The observations covered 100 infants varying in ages from 1 to 3 years with frequent and rare incidence of respiratory diseases. The diagnosis of influenza had been confirmed by serological methods: CFT and ELISA.

[Prevention of the anti-interferon effect of exogenous leukocyte interferon in children].

The preventive effect of exogenous leukocyte interferon used twice weekly at a 3-day interval in the period of an influenza epidemic as well as the effect of this preparation on the capacity of leukocytes to produce endogenous interferon were studied in young infants brought to nurseries. The observations covered 146 infants varying in ages from 11 months to 31/2 years, of them 104 infants were given interferon intranasally from an automizer (conditional experimental group) and 42 received no interferon (conditional) control group). During the period of interferon prophylaxis (5 weeks) a significant.

[Biological characteristics of influenza B viruses isolated during influenza B epidemics in 1976-1977].

Comparative studies of the antigenic structure of influenza B viruses isolated in 1976-1977 and in previous years demonstrated one-way relationship of the hemagglutinin of B/76 viruses with that of B/72 viruses. Antisera to new B/76 strains neutralized the hemagglutinating activity of all known reference influenza B virus strains beginning from 1972. Influenza B/76 viruses were divided into two groups depending on complete or partial neutralization by antiserum B/Hong Kong/7/75.

[Comparative characteristics of influenza virus A/USSR/02/76 and swine influenza virus].

Comparative studies of the biological properties, antigenic structure and ultrastructure of influenza A viruses isolated in the USSR, A/New Jersey/8/76 and A/swine/31 were carried out. Antigenic differences between A/USSR/02/76 and A/swine/31 strains as well as A/New Jersey/8/76 strain were found in the hemagglutination-inhibition and neuraminidase activity-inhibition tests. These differences were confirmed by serological examination of human sera.

[Assessment of the sensitivity of immunoprecipitation for the serodiagnosis of influenzal-bacterial pneumonias].

A comparative examination of 226 paired sera from patients with pneumonia was carried out by CFT, HI, neuraminidase activity inhibition (NI) and double immunodiffusion. A correlation of the results of agar gel precipitation and the CFT and HI tests was observed. Convalescent sera contained antibody to influenza virus ribonucleoprotein frequently, less so to its neuraminidase or hemagglutinin.

[Etiopathogenetic approach to the treatment of viral-bacterial pneumonias].

The efficacy of aerosols of leukocytal interferon used in complex with antibacterial and other medicamentous agents was studied during influenza epidemic in 1975 due to Port-Chalmers virus of influenza A with increased numbers of viral-bacterial pneumonia. The viral-sta-phylococcal etiology of the infection was confirmed in 80 per cent of the cases under stationary conditions. Various microorganism and most often Staph aureus were isolated in addition to the viruses from the patient's sputum and washings and their antibioticograms were determined.

[Comparative determination of cellular reactivity during infection with influenza virus A (H3N2)].

Among 28 strains of influenza A (H3N2) virus isolated from human patients 3 strains were found to be capable of replication in continuous monkey kidney cell cultures. When cells of different origins (PPO, chick embryo chorioallantio membrane, human nasal mucosa) were infected with the virus or when PPO were infected with allantoic or cultural virus strains, the pathological changes were of the same type. No specific inclusions were found in the cells.

[Comparative study on the properties of influenza B viruses isolated in 1959-1974].

The biological properties and antigenic structure of the following influenza B virus strains were compared: Moscow/Likh/59, Moscow/106/62, Moscow/1/66, Hong Kong/5/72, Yamagata/73 and USSR/01/4. The influenza B virus strains isolated in 1972-1974 differed by hemagglutinin from those isolated in 1959-1966. The variability of hemagglutinin correlated with that of neuraminidase.

[Distribution of exogenous interferon in experimental animals following intratracheal administration].

The distribution of homologous and heterologous interferon in rabbits after intratracheal administration was studied. The content of interferon in the lung tissue decreased 1 hour after injection. At 3 hours the interferon concentration in the lungs in some animals decreased 2-10-fold as compared with the initial.