Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress.

Mitochondria are the essential eukaryotic organelles that produce most cellular energy. The energy production and supply by mitochondria appear closely associated with the continuous shape change of mitochondria mediated by fission and fusion, as evidenced not only by the hereditary diseases caused by mutations in fission/fusion genes but also by aberrant mitochondrial morphologies associated with numerous pathologic insults. However, how morphological change of mitochondria is linked to their energy-producing activity is poorly understood.

Ambulatory 24-hour fast using flexible insulin therapy in patients with type 1 diabetes.

Aim: Prolonged fasting may be necessary in life for religious, medical and other reasons. For this reason, our study investigated the feasibility and safety of a 24-h fast conducted at home for patients with type 1 diabetes.

Research Design And Methods: Thirty-four patients with type 1 diabetes performed a 24-h complete fast at home.