Publications by authors named "Nejah F Ellouze"
Prevalence and Outcomes of Carbamazepine Toxicity in the Emergency Department: A Single-center Retrospective Study.
Indian J Crit Care Med
September 2024
Article Synopsis
- Carbamazepine (CBX) is commonly used in medicine but can cause serious toxicity, prompting a study to understand its effects and management in an emergency department.
- The research involved a review of 1,965 patient charts over 10 years, identifying 70 cases of elevated CBX levels, with chronic cases being more frequent and gastrointestinal symptoms the most common.
- Findings show that most patients had mild to moderate toxicity, with a significant number requiring hospitalization, yet none of the patients experienced fatalities, highlighting the need for careful assessment and management strategies.
Despite documented cases of baclofen toxicity in individuals with kidney disease, the drug is widely prescribed for various medical conditions, primarily spasticity, hiccups, and multiple sclerosis. Baclofen, a gamma-aminobutyric acid derivative, relies on renal excretion, rendering those with impaired kidney function susceptible to toxicity - a concern often underestimated by health-care providers. Adverse reactions, including single or double doses, are well documented in addition to multi-dose toxicity.
View Article and Find Full Text PDF