Publications by authors named "Neimar Vitor"
Article Synopsis
- * The study revealed that cyclophosphamide alone increases genomic damage and decreases phagocytosis in Swiss male mice, but combining it with the resorcinolic lipid reduces genomic damage by up to 33.8%.
- * Molecular docking shows the resorcinolic lipid binds more strongly to DNA than cyclophosphamide's active metabolite, indicating its potential as both a therapeutic candidate and a chemotherapeutic adjuvant.
Cytosporones, a class of octaketide resorcinolic lipids, have drawn the attention of researchers for exhibiting a number of notable biological properties. Herein, we describe routes to synthesize the bioactive synthetic resorcinolic lipids AMS35AA and AMS35BB with excellent overall yields using 3,5-dimethoxybenzoic acid as the starting material. The methods proved remarkably efficient to achieve the target compounds and comprise the synthesis of AMS35AA catalyzed by ascorbic acid (vitamin C).
View Article and Find Full Text PDFBackground/aim: In recent years, the search for new anticancer experimental agents derived from natural products or synthetic analogues, such as resorcinolic lipids, has received increased attention. The present study aimed to evaluate the antitumor potential, describe the cell death mechanism and the effects of 3-Heptyl-3,4,6-trimethoxy-3Hisobenzofuran-1-one (AMS35AA) in combination with different chemotherapeutic agents in the MCF-7 cell line.
Materials And Methods: Analysis of cytotoxic, genotoxic, membrane integrity, cell death and gene expression induced by the compound was performed.