Publications by authors named "Neiladri Saha"
Article Synopsis
- Detecting gene fusions, especially those involving driver oncogenes, is crucial for the clinical diagnosis and treatment of cancer, and advancements in next-generation sequencing (NGS) have improved detection methods.
- Traditional informatics methods for detecting gene fusions in RNA sequencing face challenges, including low-quality alignments and scalability issues, highlighting the need for better solutions.
- SeekFusion is introduced as an efficient and accurate pipeline specifically designed for detecting gene fusions in targeted PCR-based NGS, demonstrating superior performance compared to existing methods and successfully analyzing samples from 4,484 patients with neurological tumors and sarcomas.
Background: The success of multisite collaborative research relies on effective data collection, harmonization, and aggregation strategies. Data Coordination Centers (DCC) serve to facilitate the implementation of these strategies. The utility of a DCC can be particularly relevant for research on rare diseases where collaboration from multiple sites to amass large aggregate datasets is essential.
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