Comparative evaluation of the degree of conversion of an 8th-generation bonding agent when applied to normal dentin or caries-affected dentin, pre-treated with MMP inhibitors - An study.

Introduction: The degree of conversion of dentin bonding agents contributes to the success of final restorations in adhesive dentistry. It is clinically relevant, as it is directly related to the overall bond strength that maintains these restorations in place and prevents marginal deterioration. However, Matrix metalloproteinases (MMPs) present within the dentin substrate have been known to have a deleterious effect on the bond stability, due to their collagenolytic activity.

The Effect of Matrix Metalloproteinase Inhibitors on the Microtensile Bond Strength of Dentin Bonding Agents in Caries Affected Dentin: A Systematic Review.

Aims And Objectives: Matrix metalloproteinases (MMPs) cause degradation of the dentinal matrix, as they act actively on collagen fibrils, leading to their deterioration and collapse. MMP inhibitors are known to be used for the pre-treatment of human dentin before bonding. Most studies on the MMP inhibitors examined the effect of MMP inhibitors on bonding to sound dentin (SD), but few examine their effect on bonding to caries affected dentin (CAD).