Making patients political: Narrating, curating, enacting, and navigating the 'idealised policy patient'.

In this article we develop the concept of the 'idealised policy patient' to contribute to a better understanding of patient-family activism and the mechanisms through which powerful and persuasive patient narratives are facilitated and mobilised. The context through which we explore the idealised policy patient is the UK debates about the legalisation of mitochondrial donation, which primarily took place between 2011 and 2015. In our example, the idealised policy patient was constructed around a culturally persuasive narrative of patient suffering, where mitochondrial donation was presented as a desirable and ethical solution.

Why we need a Public Understanding of Social Science.

Who is licensed to make knowledge claims about society? A more diffuse group of individuals are afforded the status of legitimate speakers on society in the public sphere than is the case when the questions relate to the expertise of the natural sciences. We draw on the concept of the 'locus of legitimate interpretation' and the sensibilities of Collins and Evans' Studies of Expertise and Experience programme to help make sense of these issues. The social sciences are the natural sciences, and one key difference is their relationship with publics.

Join our team, change the world: edibility, producibility and food futures in cultured meat company recruitment videos.

Cultured meat is a novel technology that uses tissue engineering to expand cells taken from animals to grow muscle for consumption as food. Those supporting the technology anticipate it could radically disrupt livestock farming with, they propose, significant benefits for the environment, human health, and animal wellbeing. This paper examines the emergence of this sector through the prism of one of the leading companies - Memphis Meats - in particular focusing upon their online recruitment activity in online videos.

Os Joelhos! Os Joelhos! Protective Embodiment and Occasional Injury in .

, the African-Brazilian dance and martial art has enthusiastic devotees in Britain. Most practitioners are acutely aware of their embodiment, and have strategies to protect themselves from injury, and ways to seek treatment for any injuries they get. Drawing on data from a long-term ethnography and a set of 32 open-ended interviews with advanced students, the paper explores student strategies to prevent injuries, and their discoveries of effective remedies to recover from them, before it presents an analysis of their injury narratives using Frank's three-fold typology of illness narratives.

Spatiotemporal readiness is key to preparing regenerative medicine for the clinic.

Tweetable abstract Successful translation of regenerative medicine projects to the clinic requires attention to the complex interaction of spatial and timing issues from manufacturing to clinical use.

Cellular agriculture in the UK: a review.

This review details the core activity in cellular agriculture conducted in the UK at the end of 2019, based upon a literature review by, and community contacts of the authors. Cellular agriculture is an emergent field in which agricultural products-most typically animal-derived agricultural products-are produced through processes operating at the cellular level, as opposed to (typically farm-based) processes operating at the whole organism level. Figurehead example technologies include meat, leather and milk products manufactured from a cellular level.

Making Sense of Making Meat: Key Moments in the First 20 Years of Tissue Engineering Muscle to Make Food.

Cultured/clean/cell-based meat (CM) now has a near two decade history of laboratory research, commencing with the early NASA-funded work at Touro College and the bioarts practice of the Tissue Culture and Art project. Across this period the field, or as it is now more commonly termed, the "space," has developed significantly while promoting different visions for what CM is and can do, and the best mechanisms for delivery. Here we both analyse and critically engage with this near-twenty year period as a productive provocation to those engaged with CM, or considering becoming so.

Bringing cultured meat to market: Technical, socio-political, and regulatory challenges in cellular agriculture.

Background: Cultured meat forms part of the emerging field of cellular agriculture. Still an early stage field it seeks to deliver products traditionally made through livestock rearing in novel forms that require no, or significantly reduced, animal involvement. Key examples include cultured meat, milk, egg white and leather.

Blood, meat, and upscaling tissue engineering: Promises, anticipated markets, and performativity in the biomedical and agri-food sectors.

Tissue engineering is a set of biomedical technologies, including stem cell science, which seek to grow biological tissue for a diversity of applications. In this paper, we explore two emergent tissue engineering technologies that seek to cause a step change in the upscaling capacity of cell growth: cultured blood and cultured meat. Cultured blood technology seeks to replace blood transfusion with a safe and affordable bioengineered replacement.

Doing laboratory ethnography: reflections on method in scientific workplaces.

Laboratory ethnography extended the social scientist's gaze into the day-to-day accomplishment of scientific practice. Here we reflect upon our own ethnographies of biomedical scientific workspaces to provoke methodological discussion on the doing of laboratory ethnography. What we provide is less a 'how to' guide and more a commentary on what to look for and what to look at.

Three persons, three genetic contributors, three parents: Mitochondrial donation, genetic parenting and the immutable grammar of the 'three x x'.

In 2015, two novel in vitro fertilisation techniques intended to prevent the inheritance of mitochondrial disease were legalised in the United Kingdom, following an intense period of inquiry including scientific reviews, public consultations, government guidance and debates within the Houses of Parliament. The techniques were controversial because (1) they introduced a third genetic contributor into the reproductive process and (2) they are germline, meaning this genetic change could then be passed down to subsequent generations. Drawing on the social worlds framework with a focus on implicated actors and discursive strategies, this article explores key features of the UK mitochondrial debates as they played out in real time through policy documents and public debate.

Promise and Ontological Ambiguity in the Meat Imagescape: From Laboratory Myotubes to the Cultured Burger.

meat (IVM), also known as cultured meat, involves growing cells into muscle tissue to be eaten as food. The technology had its most high-profile moment in 2013 when a cultured burger was cooked and tasted in a press conference. Images of the burger featured in the international media and were circulated across the Internet.

The first bite: Imaginaries, promotional publics and the laboratory grown burger.

In this article, we analyse a 2013 press conference hosting the world's first tasting of a laboratory grown hamburger. We explore this as a media event: an exceptional performative moment in which common meanings are mobilised and a connection to a shared centre of reality is offered. We develop our own theoretical contribution - the promotional public - to characterise the affirmative and partial patchwork of carefully selected actors invoked during the burger tasting.

A Pilot Examination of a Mosque-Based Physical Activity Intervention for South Asian Muslim Women in Ontario, Canada.

Low levels of physical activity have been reported in South Asian Muslim women. Mosques could be beneficial in providing physical activity opportunities for Muslim women. This study examined the feasibility, acceptability and effectiveness of a mosque-based physical activity program for South Asian Muslim women in Canada.

Closure of a human tissue biobank: individual, institutional, and field expectations during cycles of promise and disappointment.

Biobanks are increasingly being established to act as mediators between patient-donors and researchers. In practice, some of these will close. This paper details the experiences of one such bank.

Unexpected tissue and the biobank that closed: an exploration of value and the momentariness of bio-objectification processes.

Unanticipated situations can arise in biobanking. This paper empirically documents unexpected situations at the anonymous biobank 'Xbank'. Firstly, Xbank received an unexpected and significant quantity of tissue from the historical archive of a hospital network.

How to offer culturally relevant type 2 diabetes screening: lessons learned from the South asian diabetes prevention program.

The literature on diabetes mellitus in the South Asian population clearly states the high-risk status of this group, yet there is a lack of effective models of culturally relevant, community-based screening and education programs for such a group. The South Asian Diabetes Prevention Program (SADPP) was developed to enhance equitable access to diabetes prevention resources for the South Asian communities in Toronto by offering language-specific and culturally relevant services. The SADPP model works through 3 participant education sessions plus an additional attachment and enrolment component.

Closing the regulatory regress: GMP accreditation in stem cell laboratories.

Contemporary biomedical research is conducted amidst regimes of national and transnational regulation. Regulation, like rules generally, cannot specify all the practicalities of their application. Regulations for biomedical research impose considerable constraints on laboratories and others.

Documenting the doable and doing the documented: bridging strategies at the UK Stem Cell Bank.

We explore the local negotiation of regulatory practice at the UK Stem Cell Bank, the first Bank of its type in the world. Basing our empirical work on a detailed analysis of one aspect of the Bank's regulatory commitment--the completion of the Cell Line Information form--we make visible the necessary judgements and labour involved in interpreting and operationalizing externally imposed regulation. The discussion opens by detailing the problems encountered when the Bank completes the form: reconciling a bureaucratic system of accountability with craft-like laboratory skills involving multiple kinds of tacit knowledge.

Social science in a stem cell laboratory: what happened when social and life sciences met.

We describe the experience of conducting intensive social science research at the UK Stem Cell Bank from the viewpoint of both the person conducting the social science research and the Director of the Bank. We detail the initial misunderstandings and concerns held by both and the problems these caused. Then we describe how the relationship developed as the project progressed and shared benefits became apparent.

A social science view on the FRAME symposium: identities and networks.

This paper, written by two social scientists, presents a social science perspective on the issues raised at the FRAME symposium on Human Alternatives to Animal Studies. Drawing upon the authors' experience of conducting research with stem cell scientists, issues around access to human tissue for in vitro uses are considered. The paper concludes by raising questions pertinent to both interested social scientists and the Three Rs agenda.