Tacrolimus: in vitro effects on myelopoiesis, apoptosis, and CD11b expression.

Background: Tacrolimus is a common component of multi-drug immunosuppressive regimens that are used for the prevention of rejection in transplant recipients. Tacrolimus therapy has been associated with anemia after transplantation, and recent clinical evidence in children suggests its association with the development of neutropenia for which an alternative etiology is not apparent. Mechanisms of suspected tacrolimus-related neutropenia have not been previously elucidated.

Endophthalmitis caused by Klebsiella species.

Purpose: To investigate clinical settings, antibiotic sensitivities, and visual outcomes associated with endophthalmitis caused by Klebsiella species.

Design: Retrospective case series.

Methods: Record review of patients with endophthalmitis caused by Klebsiella (1984 through 2003).