Publications by authors named "Neil Kidambi"

Article Synopsis
  • Schizophrenia is a serious mental illness that typically starts in late adolescence or early adulthood, causing significant difficulties in various areas of life, and its underlying causes are still largely unknown.
  • The dopamine hypothesis has guided research into the illness, but recent studies highlight the potential role of acetylcholine (ACh), particularly through a combination treatment of the muscarinic agonist xanomeline and the antagonist trospium, which improved tolerability in patients.
  • A clinical trial with this combination showed greater improvements in symptoms for those receiving the treatment compared to placebo, leading researchers to explore the cholinergic system as a promising avenue for better schizophrenia therapies, with further studies ongoing.
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Nearly 90% of Americans are exposed to a traumatic event at some point in their lives, and over 8% of those individuals will develop posttraumatic stress disorder (PTSD). Our study examined the demographic differences and psychiatric comorbidities in inpatients with PTSD with and without somatic symptom disorders (SSDs), using data from the Nationwide Inpatient Sample for 2018 and 2019. Our sample included 12,760 adult patients with a primary diagnosis of PTSD, which was further subdivided based on a codiagnosis of SSD.

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Frontotemporal dementia (FTD) is the most common cause of neurocognitive decline, second to Alzheimer's disease (AD) and Lewy body dementia. Its presence offers a unique challenge to physicians trying to detect cognitive deficits, as it not only arises in middle age but also can be misdiagnosed as a primary psychiatric disorder. The following case describes the clinical course of a 50-year-old male with a recent history of sporadic visual and auditory hallucinations, followed by a gradual decline in cognitive function including declining memory, apathy and behavioral disinhibition, and social functioning, which are suggestive of FTD-type.

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Psychosis presents with hallucinations, delusions, disorganized speech, abnormal psychomotor behavior, and negative symptoms. It most commonly appears in the setting of schizophrenia, although it could also appear in bipolar disorder, major depression, post-traumatic stress disorder (PTSD) and even in medical conditions and substance use. In young people, the diagnosis of psychosis can present as a challenge due to the overlap of psychotic conditions and other emotional, behavioral, and developmental disorders.

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