Noninvasive measurement of tracer extraction efficiency in tissue, illustrated with Tc-99m-MAG3.

Objective: The aim of this study is to develop a noninvasive technique for measuring tissue tracer extraction efficiency ( E ) and illustrate it for Tc-99m-mercaptoacetyltriglycine (MAG3) and kidney.

Methods: E was measured in 10 patients with normal MAG3 renography. E is the ratio of tissue clearance-to-blood flow ( Ki/F ).

Errors in measurement of glomerular filtration rate using the slope-intercept technique and their identification.

Background: GFR measured from plasma sampling may be expressed as slope-intercept GFR (SI-GFR) and scaled to body surface area (mGFR/BSA) or as GFR per unit extracellular fluid volume (mGFR/ECV), which is based only on half-time. Measurement errors comprise 3 categories. Pre-injection error arises from error in administered marker and is suspected when mGFR/BSA and mGFR/ECV disagree.

Evaluation of the contamination droplet model used for the assessment of skin dose during the manipulation of radiopharmaceuticals.

The manipulation of radiopharmaceuticals in nuclear medicine can result in the droplet contamination of operators resulting in the accumulation of a significant skin dose. Current methods to estimate this skin dose often utilise a 50l cylindrical droplet model, which can lead to unrealistically high estimated skin doses for some radiopharmaceuticals. By conducting experiments to measure the volume of real droplets arising from simulating the manipulation of radiopharmaceuticals, this work found that 50l is an overestimation of a realistic contamination droplet.

Estimated glomerular filtration rate equations in people of self-reported black ethnicity in the United Kingdom: Inappropriate adjustment for ethnicity may lead to reduced access to care.

Assessment in African populations suggest adjustment for ethnicity in estimated glomerular filtration rate (eGFR) equations derived from African Americans lead to overestimation of GFR and failure to determine severity in chronic kidney disease (CKD). However, studies in African Europeans are limited. We aimed to assess accuracy of eGFR equations, with and without ethnicity adjustment compared with measured GFR in people of Black ethnicity in the United Kingdom.

75SeHCAT whole body retention for unexplained chronic diarrhoea based on early first whole body counting.

Background: There are many protocol variations in the whole-body 75SeHCAT retention test [whole-body retention (WBR)] for investigation of bile acid diarrhoea. The time between capsule consumption and first count, however, is widely taken, without debate, to be 3 h. In the Covid-19 era, it is desirable to limit the time patients spend in the department.