Differential scanning calorimetry of gliomas: a new tool in brain cancer diagnostics?

Background: Thermal stability signatures of complex molecular interactions in biological fluids can be measured using differential scanning calorimetry (DSC). Evaluating the thermal stability of plasma proteomes offers a method of producing a disease-specific "signature" (thermogram) in neoplastic and autoimmune diseases.

Objective: The authors describe the use of DSC with human brain tumor tissue to create unique thermograms for correlation with histological tumor classification.