Publications by authors named "Neil D Dattani"
Emergency Department Volume and Outcomes for Patients After Chest Pain Assessment.
Circ Cardiovasc Qual Outcomes
November 2018
Background: Chest pain is one of the most common reasons for emergency department (ED) visits in developed countries. Whether higher volume EDs have better outcomes, specifically for patients with chest pain, is unknown and pertinent.
Methods And Results: We conducted a study using population-based data on 498 291 patients ≥40 years old, presenting to ED in Ontario, Canada from 2008 to 2014, with chest pain and were discharged after assessment.
Objectives: Emergency medicine (EM) residents face many challenges during residency. Given the negative effects of residency training and the paucity of information on EM resident wellness experiences, we conducted a national survey to characterize the current landscape of Canadian EM resident wellness.
Methods: A cross-sectional study of Canadian EM residents was done using an online survey created by a Canadian Association of Emergency Physicians Resident Section working group on wellness.
Article Synopsis
- The study aimed to see how comorbidities and high-risk medications influence how often older patients visit their family doctors.
- Researchers reviewed charts of patients aged 65 and older to identify the top and bottom 5% of frequent visitors, resulting in a sample of 265 patients.
- Key findings showed that being female, over 85 years old, and taking more medications were significant predictors of frequent visits, while traditional health assessment tools did not effectively predict visit frequency.
Objectives: A P-value <0.05 is one metric used to evaluate the results of a randomized controlled trial (RCT). We wondered how often statistically significant results in RCTs may be lost with small changes in the numbers of outcomes.
View Article and Find Full Text PDFCells sense and respond to changes in oxygen concentration through gene regulatory processes that are fundamental to survival. Surprisingly, little is known about how anemia affects hypoxia signaling. Because nitric oxide synthases (NOSs) figure prominently in the cellular responses to acute hypoxia, we defined the effects of NOS deficiency in acute anemia.
View Article and Find Full Text PDFObjective: To investigate the impact of industry funding on reporting of subgroup analyses in randomised controlled trials.
Design: Systematic review.
Data Sources: Medline.
Purpose: Clinical studies demonstrate that anemia increases the risk of morbidity and mortality. Tissue hypoxia is an attractive but incompletely characterized candidate mechanism of anemia-induced organ injury. Physiological responses that optimize tissue oxygen delivery (nitric oxide synthase-NOS) and promote cellular adaptation to tissue hypoxia (hypoxia inducible factor-HIF) may reduce the risk of hypoxic organ injury and thereby improve survival during anemia.
View Article and Find Full Text PDFBackground: Perioperative beta-blockade and anemia are independent predictors of increased stroke and mortality by undefined mechanisms. This study investigated the effect of beta-blockade on cerebral tissue oxygen delivery in an experimental model of blood loss and fluid resuscitation (hemodilution).
Methods: Anesthetized rats were treated with metoprolol (3 mg x kg) or saline before undergoing hemodilution with pentastarch (1:1 blood volume exchange, 30 ml x kg).