Publications by authors named "Neil A B Adia"
Orthoflaviviruses are positive-sense single-stranded RNA viruses that hijack host proteins to promote their own replication. Zika virus (ZIKV) is infamous among orthoflaviviruses for its association with severe congenital birth defects, notably microcephaly. We previously mapped ZIKV-host protein interactions and identified the interaction between ZIKV non-structural protein 4A (NS4A) and host microcephaly protein ankyrin repeat and LEM domain-containing 2 (ANKLE2).
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- Autophagy plays a crucial role in various diseases, making it a promising target for therapies, yet its mechanisms are still not fully understood due to limited systematic measurements.
- Recent studies by Loos et al. (2014) and Beesabathuni et al. (2022) have introduced methods for quantitatively measuring autophagy, which could help clarify its role in diseases.
- This commentary discusses unresolved questions in autophagy research and highlights the importance of rate measurements for developing cancer treatments and understanding virus interactions, suggesting a need for advanced screening methods to unravel autophagy's complexities.