Naphthoquinones biflorin and bis-biflorin () as possible inhibitors of the fungus polymerase: molecular docking, molecular dynamics, MM/GBSA calculations and drug-likeness study.

A new worldwide concern has emerged with the recent emergence of infections caused by . This reflects its comparative ease of transmission, substantial mortality, and the increasing level of resistance seen in the three major classes of antifungal drugs. Efforts to create a better design for structure-based drugs that described numerous modifications and the search for secondary metabolic structures derived from plant species are likely to reduce the virulence of several fungal pathogens.

Combined study of docking and molecular dynamics against DNV-3 SN1 protein by bixinoids.

Dengue (DENV), Zica virus (ZIKV), and Chikungunya fever (CHIK) are tropical diseases that have caused a lot of problems in general worldwide. Transmitted by mosquitoes of the species and , they have not been completely eradicated in the country, and their proliferation has only increased in the Northeast region. Within the structure of the virus, it is possible to verify the presence of glycoprotein SN1, which is responsible for its replication.