Impact of single nucleotide polymorphism in tumor necrosis factor-α gene 308G/A in Egyptian asthmatic children and wheezing infants.

Bronchial asthma is a common disease with multiple determinants that include genetic variation. Although tumor necrosis factor alpha (TNF-α) is a major pro-inflammatory cytokine, the functions of genetic polymorphisms in this cytokine has not been thoroughly examined in the context of asthma pathology. Therefore, we aimed to investigate whether single nucleotide polymorphism (SNP) in TNF-α is associated with asthma and wheezing and whether the association is related to the severity of the disease and other epidemiological factors.

Aetiology and management of extrahepatic portal vein obstruction in children: King's College Hospital experience.

Objective: To study a single-centre experience of the management of extrahepatic portal vein obstruction (EHPVO) in children during the last 3 decades.

Materials And Methods: The medical records of 108 children (67 male, median age 4.75 years, range = 1 day-16.