Unraveling the effect of spermidine on biochemical, anatomical and yield attributes in chickpea under chloride dominated salinity.

This study investigates the effect of foliar application of spermidine (Spd) on salt-stressed chickpea genotypes under natural environmental conditions. Four chickpea genotypes were treated with chloride-dominated salinity levels of 4.0 and 8.

Nitroaromatic Compounds Dictate Electrochemical Properties of by Manipulating the Cellular Membrane.

Nitroaromatic compounds (NACs) are generally used as starting materials and/or generated as byproducts during the manufacturing of dyes, fertilizers, and therapeutic agents. Though NACs are beneficial when used appropriately, inadequate management, disposal, and application methods have led to their introduction to bacterial ecosystems where NACs act as mutagenic agents and may even contribute to antimicrobial resistance. Many of these bacterial systems are known to have different pathways to adapt to the presence of NACs such as altering the lipid composition of cellular membranes and intracellular degradation of NACs.

Probing Rotational Decoherence with a Trapped-Ion Planar Rotor.

The quantum rotor is one of the simplest model systems in quantum mechanics, but only in recent years has theoretical work revealed general fundamental scaling laws for its decoherence. For example, a superposition of orientations decoheres at a rate proportional to the sine squared of the angle between them. Here, we observe scaling laws for rotational decoherence dynamics for the first time, using a 4  μm diameter planar rotor composed of two Paul-trapped ions.

Neurophysiological and Cognitive Changes Induced by the Acute Head-Down Tilt.

Introduction: In space, under weightlessness conditions, human brain activity is changed due to the shifting of body fluid and blood toward the cephalic region. This shifting leads to changes in cerebral hemodynamics and, consequently, neurophysiological function, which impacts mental functions like cognition and decision-making capabilities of space travelers. The present study reports the effect of acute exposure to simulated microgravity on cognitive functions and event-related potentials.

Role of Adenosine A1 Receptor in Sleep Deprivation-Induced Neuroinflammation: Insights on Rapid Eye Movement Sleep and Fear Extinction Memory Recall in Rats.

Introduction: Sleep deprivation (SD), stemming from a myriad of aetiologies, is a prevalent health condition frequently overlooked. It typically impairs memory consolidation and synaptic plasticity, potentially through neuroinflammatory mechanisms and adenosinergic signalling. It is still unclear whether the adenosine A1 receptor (A1R) modulates SD-induced neurological deficits in the hippocampus.

Overzealous over-the-counter cough syrup ingestion leading to serious manifestation in a child - A case report.

Cough is a protective reflex that allows clearance of secretions from upper respiratory tract. It is not a disease by itself but a symptom of underlying disease. In a majority of cases, it is self-limiting and requires only supportive care.

Challenges and opportunities in engineering next-generation 3D microelectronic devices: improved performance and higher integration density.

In recent years, nanotechnology and materials science have evolved and matured, making it increasingly easier to design and fabricate next-generation 3D microelectronics. The process has changed drastically from traditional 2D microelectronics, resulting in improved performance, higher integration density, and new functionalities. As applications become more complex and power-intensive, this technology can address the demands of high-performance computing, advanced sensors, and cutting-edge communication systems wearable, flexible devices, To manufacture higher-density microelectronics, recent advances in the fabrication of such 3D devices are discussed.

Intrinsically Antibacterial Carbon Nanoparticles Optimally Entangle into Polymeric Films to Produce Composite Packaging.

The quality of food, pharmaceutical, or sustainability products is generally maintained through optimal storage conditions or the use of packaging films. Herein, an intrinsically antibacterial and improvised polylactic acid-based film (-PLA-film) has been produced by introducing a microwave-assisted synthesis process of carbon nanoparticles produced from hemp fibers (CNPs). These high-performance packaging (-PLA) films were produced with different percentages of loaded CNPs, i.

Evaluating health risks of PM-bound heavy elements in Faridabad, Haryana (India): an industrial perspective.

The present study is focused on investigating the heavy/toxic metals (Al, Ni, Cr, Pb, Cu, As, Mn, and Zn) of PM and assessing their associated human health risks. During the study period (July 2022 to July 2023), the PM samples were collected from two distinct sites in Faridabad (92 samples from site 1 and 85 samples from site 2). In this study, the US EPA's Risk Assessment Guidance for Superfund (RAGS) was followed to evaluate the human health risk associated with PM-bound heavy elements.

Orotic acid-capped Tb(III)-doped calcium sulphate nanorods for the selective detection of tryptophan.

Lanthanide-based luminescent materials have gained huge attention due to their applications in optoelectronic devices, sensing, bio-imaging, anti-counterfeiting, and more. In this work, we report a luminescence-based sensor for the detection of tryptophan using orotic acid-capped Tb-doped CaSO nanorods (NRs). Orotic acid (OA) was found to play a dual role as a capping agent to control the growth of the nanorods and as a sensitizer for Tb ions.

LC-Orbitrap HRMS-Based Proteomics Reveals Novel Mitochondrial Dynamics Regulatory Proteins Associated with Induced Glioblastoma (GBM) of .

Glioblastoma multiforme (GBM) is the most prevalent and aggressive brain tumor found in adult humans with a poor prognosis and average survival of 14-15 months. In order to have a comprehensive understanding of proteome and identify novel therapeutic targets, this study focused mainly on the differentially abundant proteins (DAPs) of -induced GBM. is a constitutively active Ras mutant form essential for tumor progression by continuously activating signaling pathways leading to uncontrolled tumor growth.

Fractal dimension and lacunarity measures of glioma subcomponents are discriminative of the grade of gliomas and IDH status.

Since the overall glioma mass and its subcomponents-enhancing region (malignant part of the tumor), non-enhancing (less aggressive tumor cells), necrotic core (dead cells), and edema (water deposition)-are complex and irregular structures, non-Euclidean geometric measures such as fractal dimension (FD or "fractality") and lacunarity are needed to quantify their structural complexity. Fractality measures the extent of structural irregularity, while lacunarity measures the spatial distribution or gaps. The complex geometric patterns of the glioma subcomponents may be closely associated with the grade and molecular landscape.

Multidetector Computed Tomography Used in Evaluation of Olfactory Fossa Depth in a Tertiary Hospital in Eastern Region of Nepal: A Descriptive Cross-sectional Study.

Introduction: Olfactory fossa (OF) is a depression in most infero-medial portion of anterior cranial fossa formed by cribriform plate, crista galli and lateral lamella of cribriform plate (LLCP). LLCP being thinnest and extremely variable parts, more prone for iatrogenic injury during sinus surgery in case of asymmetric and deep OF. Multidetector computed tomography (MDCT) is frequently used imaging modality in the evaluation of paranasal sinus.

Analysis of the gamma index using an indigenously developed anthropomorphic heterogeneous female pelvis (AHFP) phantom.

Background: It is essential in modern radiotherapy treatment practices to evaluate the quality assurance (QA) of the treatment plan prior to the exclusion of patient from treatment. The typical suitable tools used for patient pretreatment QA are phantoms representing the human anatomy. An anthropomorphic heterogeneous female pelvic (AHFP) phantom has been developed to represent the real female pelvic structure.

Role of Cytochrome P450 3A4 in Cancer Drug Resistance: Challenges and Opportunities.

One of the biggest obstacles to the treatment of diseases, particularly serious conditions like cancer, is therapeutic resistance. The process of drug resistance is influenced by a number of important variables, including MDR genes, drug efflux, low-quality medications, inadequate dosage, etc. Drug resistance must be addressed, and new combinations based on the pharmacokinetics/pharmacodynamics (PK-PD) characteristics of the partner pharmaceuticals must be developed in order to extend the half-lives of already available medications.

Androgen Signaling in Prostate Cancer: When a Friend Turns Foe.

Androgen (AR) signaling is the main signaling for the development of the prostate and its normal functioning. AR is highly specific for testosterone and dihydrotestosterone, significantly contributing to prostate development, physiology, and cancer. All these receptors have emerged as crucial therapeutic targets for PCa.

Effect of GA and calcium on growth, biochemical, and fatty acid composition of linseed under chloride-dominated salinity.

The accumulation of salts in soil is an environmental threat affecting plant growth and crop yield. Linseed or flax is an ancient crop that has multifarious utilities in terms of industrial oil, textile fiber, and products. Salt susceptibility adversely affects linseed production, particularly to meet the growing demand for nutritional and nutraceutical products.

Second stem cell transplantation for treatment of relapsed/refractory multiple myeloma after first autologous stem cell transplant: A 15-year retrospective institutional analysis.

Background: Multiple myeloma remains an incurable disease, with the majority of patients relapsing after autologous stem cell transplant (ASCT). After relapse, second transplant remains one of the therapeutic options, along with novel agents.

Methods: We reviewed the data of our patients who underwent ASCT for myeloma (N = 202) over the last two decades (2004-2019).

Development of an Anthropomorphic Heterogeneous Female Pelvic Phantom and Its Comparison with a Homogeneous Phantom in Advance Radiation Therapy: Dosimetry Analysis.

Background: Accurate dosimetry is crucial in radiotherapy to ensure optimal radiation dose delivery to the tumor while sparing healthy tissues. Traditional dosimetry techniques using homogeneous phantoms may not accurately represent the complex anatomical variations in cervical cancer patients, highlighting the need to compare dosimetry results obtained from different phantom models.

Purpose: The aim of this study is to design and evaluate an anthropomorphic heterogeneous female pelvic (AHFP) phantom for radiotherapy quality assurance in cervical cancer treatment.