Publications by authors named "Neha V Bokil"
Somatic cells of human males and females have 45 chromosomes in common, including the "active" X chromosome. In males the 46 chromosome is a Y; in females it is an "inactive" X (Xi). Through linear modeling of autosomal gene expression in cells from individuals with zero to three Xi and zero to four Y chromosomes, we found that Xi and Y impact autosomal expression broadly and with remarkably similar effects.
View Article and Find Full Text PDFSomatic cells of human males and females have 45 chromosomes in common, including the "active" X chromosome. In males the 46 chromosome is a Y; in females it is an "inactive" X (Xi). Through linear modeling of autosomal gene expression in cells from individuals with zero to three Xi and zero to four Y chromosomes, we found that Xi and Y impact autosomal expression broadly and with remarkably similar effects.
View Article and Find Full Text PDFArticle Synopsis
- Germline genes that are improperly expressed in non-germline cancer cells could be valuable targets for diagnosis and therapy due to their limited normal expression and ability to activate broadly across cancer types.
- Components of the PIWI-interacting small RNA (piRNA) pathway are particularly noteworthy as they can help maintain genome stability in germ cells.
- The study finds that while some piRNA-pathway genes are expressed in cancer, functional piRNA-silencing complexes are not formed, and the presence of a PIWI protein does not significantly affect cancer cell gene activity, suggesting that piRNA silencing is not commonly reactivated in cancer.