Publications by authors named "Neha Rawat"

Fluoride exposure primarily occurs through contaminated water and leads to fluorosis, which is a global health concern. After ingestion, fluoride is absorbed via gastrointestinal tract, where it interacts with the gut microbiota. While animal studies have explored fluoride's effects on gut microbiota, no human studies have yet been conducted.

View Article and Find Full Text PDF

Planktonic pathogens pose a significant threat to the global community, especially as they develop into microbial biofilms. Pseudomonas aeruginosa, a gram-negative bacillus, is notorious for causing nosocomial infections and can easily transform into a multidrug-resistant form, particularly within biofilms. This transformation leads to chronic infections in immunocompromised individuals, increasing morbidity and mortality rates worldwide.

View Article and Find Full Text PDF

Fluorosis, a debilitating disease, causes dental mottling and bone deformities among other adverse health effects. The current epidemiological study focused on the prevalence and risk factors of fluorosis in the fluoride endemic village, Dongargaon, Maharashtra, India. The clinical diagnosis of subjects showed 96.

View Article and Find Full Text PDF

Deep Eutectic Solvents (DESs) emerge as innovative 21st-century solvents, supplanting traditional ones like ethanol and n-hexane. Renowned for their non-toxic, biodegradable, and water-miscible nature with reduced volatility, DESs are mostly synthesized through heating and stirring method. Physicochemical properties such as polarity, viscosity, density and surface tension of DESs influenced their application.

View Article and Find Full Text PDF

Extraction of bioactive compounds for application in nutraceuticals is gaining popularity. For this, there is a search for low-cost substrates that would make the end product and the process more economical. Mushroom waste (stalk, cap, stem etc.

View Article and Find Full Text PDF

Research for alternative sources for producing renewable energy is rising exponentially, and consequently, microbial fuel cells (MFCs) can be seen as a promising approach for sustainable energy production and wastewater purification. In recent years, MFC is widely utilized for wastewater treatment in which the removal efficiency of heavy metal ranges from 75-95%. They are considered as green and sustainable technology that contributes to environmental safety by reducing the demand for fossil fuels, diminishes carbon emissions, and reverses the trend of global warming.

View Article and Find Full Text PDF

The initiation of the "nanotechnology era" within the past decade has been prominently marked by advancements in biomaterials. This intersection has opened up numerous possibilities for enhancing the detection, diagnosis, and treatment of various illnesses by leveraging the synergy between biomaterials and nanotechnology. The term "nano biomaterials" referring to biomaterials featuring constituent or surface feature sizes below 100 nm, presents a realm of extraordinary materials endowed with unique structures and properties.

View Article and Find Full Text PDF

Background: SARS-CoV-2 infections caused mild-to-moderate illness. However, a sizable portion of infected people experience a rapid progression of hyper-inflammatory and hypoxic respiratory illness that necessitates an effective and safer remedy to combat COVID-19.

Methods: A total of 150 COVID-19-positive patients with no to mild symptoms, between the age groups 19-65 years were enrolled in this randomized, open-labeled three-armed clinical trial.

View Article and Find Full Text PDF

The persistence of drug resistance poses a significant obstacle to the advancement of efficacious malaria treatments. The remarkable efficacy displayed by 1,2,3-triazole-based compounds against Plasmodium falciparum highlights the potential of triazole conjugates, with diverse pharmacologically active structures, as potential antimalarial agents. We aimed to synthesize 7-dichloroquinoline-triazole conjugates and their structure-activity relationship (SAR) derivatives to investigate their anti-plasmodial activity.

View Article and Find Full Text PDF
Article Synopsis
  • Fluoride and arsenic are significant contaminants in water and soil, posing risks to various life forms.
  • A study focused on a bacterium, strain IR-1, revealed its ability to tolerate and grow in the presence of both fluoride and arsenic.
  • Results indicated that arsenic may reduce fluoride toxicity to IR-1, suggesting the bacterium could be useful for restoring contaminated soil environments.
View Article and Find Full Text PDF

Background: Tetralogy of Fallot is a severe type of congenital heart disease (CHD) and one of the leading indirect causes of mortality & morbidity among women with CHD. We came across a rare case of an uncorrected Tetralogy of Fallot with pulmonary atresia and major aortopulmonary collateral arteries in pregnancy.

Case Presentation: We are reporting the challenges in managing a pregnancy of 25-years-old G3 P0110, previous one stillbirth and who was diagnosed to have congenital heart disease during pregnancy following spontaneous abortion.

View Article and Find Full Text PDF

Introduction: Hemodialysis (HD) requires blood exposure to infectious materials through the extracorporeal circulation for a prolonged period, and exposure to risk factors for nosocomial infections is always there.

Aims And Objectives: To determine the prevalence of hepatitis B and hepatitis C in patients undergoing hemodialysis and evaluate the various modes of transmission involved in the causation of the infection.

Materials And Methods: A total of 60 patients with chronic kidney disease, admitted to our hospital for HD, were screened for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies.

View Article and Find Full Text PDF
Article Synopsis
  • Improper disposal of animal-derived waste can harm the environment, but advancements in biotechnology allow for its transformation into useful biomaterials.
  • Veterinary and agricultural by-products like poultry, cattle, sheep, and pig waste can be repurposed into items such as biopolymers, scaffolds, and collagen, benefiting various industries.
  • There’s a need for standardized protocols and government policies to support a sustainable supply chain for these biomaterials, alongside the development of a circular bioeconomy to ensure environmentally friendly practices.
View Article and Find Full Text PDF

Background The importance of optimal acid-base balance during renal transplant surgeries cannot be stressed enough. Optimal preload and electrolyte balance is important in maintaining this. There has been a debate on the choice of perioperative crystalloids in renal transplant surgeries over the past decades.

View Article and Find Full Text PDF

Rawat N, Sahni N, Yaddanapudi L. In Response to "Balanced Salt Solution for Metabolic Acidosis in ICU". Indian J Crit Care Med 2021;25(2):237.

View Article and Find Full Text PDF

Background: Many countries have developed their core set of STR loci for forensic application and database generation, which India lacks.

Aim: To assess the usefulness of various combinations of autosomal STR marker sets for their superior use in the central Indian population for forensic and paternity applications.

Subjects And Methods: 19 STR marker sets were analysed on 200 central Indian populations and 20 paternity cases to assess their usefulness.

View Article and Find Full Text PDF
Article Synopsis
  • - The study compares the effectiveness of Ringer's Lactate (RL) and Acetate Solution (AC) for correcting metabolic acidosis in critically ill patients, with a focus on time to correction and overall effectiveness.
  • - Conducted on 50 ICU patients, results showed no significant difference in the speed or level of metabolic acidosis correction between the two fluids, although AC was more expensive.
  • - The findings suggest that both RL and AC are equally effective for treating metabolic acidosis, highlighting that cost does not correlate with better patient outcomes in this case.
View Article and Find Full Text PDF

Forensic DNA typing and subsequent molecular methods of sex determination in humans have been proven to be an imperious tool to criminal justice system. In current practice, most of the short tandem repeat (STR) based commercial kits contain amelogenin as the sexing marker. Amelogenin gene which contributes to the tooth enamel formation is present on both X and Y chromosome with a variation in base pair size.

View Article and Find Full Text PDF

Drug discovery is generally considered as a costly affair and it takes approximately 15 years to reach a new chemical entity into the market. Among the recent potent drug molecules with most effective pharmacological properties, very few reached for Phase I clinical trial in humans. Unfortunately, the historical average reveals an almost 90% overall attrition rate in clinical trials.

View Article and Find Full Text PDF

Deficiency of vitamin D is a global concern affecting a huge number of human populations. This deficiency has a serious impact on human health not only affecting bone mineral density but also becoming the reason for cardiovascular disorders, infectious diseases, autoimmune diseases and cancers. Exposure to sunlight is the major source of vitamin D, but due to the present day-to-day lifestyle of working in a shade arouses the need for exogenous sources of vitamin D.

View Article and Find Full Text PDF

Cisplatin is a potent and widely used chemotherapeutic agent to treat a variety of tumors. However, its clinical use is associated with undesirable side effects and acquired resistance to cisplatin. In this study, cisplatin loaded hyaluronic acid (HA) functionalized poly (lactic-co-glycolic acid)-poly (ethylene glycol) nanoparticles (CP-HA-PLGA-PEG-NPs) were fabricated using double emulsion solvent evaporation method to target CD44 receptor expressed on cancerous cells.

View Article and Find Full Text PDF

Arsenic-contaminated areas of Sanganer, Jaipur, Rajasthan, India were surveyed for the presence of metal resistant bacteria contaminated with textile effluent. Samples were collected from soil receiving regular effluent from the textile industries located at Sanganer area. The properties like pH, electrical conductivity, organic carbon, organic matter, exchangeable calcium, water holding capacity and metals like arsenic, iron, magnesium, lead and zinc were estimated in the contaminated soil.

View Article and Find Full Text PDF

Synopsis of recent research by authors named "Neha Rawat"

  • - Neha Rawat's recent research focuses on innovative methodologies and materials to enhance environmental sustainability and health applications, particularly in the fields of deep eutectic solvents, extraction of bioactives from waste, and advanced nanobiomaterials.
  • - Her studies demonstrate the extensive utility of deep eutectic solvents in food applications and highlight the potential of microbial fuel cells for energy production and wastewater treatment, showcasing impressive removal efficiencies of heavy metals.
  • - Additionally, her clinical research includes investigations into the therapeutic effects of traditional herb extracts on COVID-19, and exploration of new antimalarial compounds, ultimately addressing significant health challenges while contributing to the understanding of environmental and biological interactions.

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session4lqiequjfgcqbgd5l771ts7cnq6hm56k): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once