Comparison of Low Dose Recombinant Factor VIIa and 4-Factor Prothrombin Complex Concentrate for Treatment of Bleeding Related to Cardiac Surgery.

Recombinant factor VIIa (rFVIIa) and prothrombin concentrate complex (PCC) are used for uncontrolled bleeding in cardiac surgery (CS), however, there are limited direct comparisons of these agents. To evaluate the efficacy and safety of rFVIIa and PCC in CS related bleeding. This retrospective study included adult CS patients who received either low dose rFVIIa (30 mcg/kg) or 4-factor PCC.