Publications by authors named "Negar Zafarian"
Article Synopsis
- HTLV-1 is linked to serious health issues like Adult T-cell Leukemia/Lymphoma and HAM/TSP; thus, screening potential organ donors for the virus is vital due to high transmission risks, particularly in kidney transplant recipients.
- A study at the Iranian Tissue Bank from 2014 to 2021 found that 3% of 3,814 potential organ/tissue donors tested positive for HTLV-1, with rates significantly dropping from 6% to 0.5% over the years.
- Females showed a higher positivity rate (4%) than males (2%), and donors with brain death had a much lower infection rate (0.2%) compared to those with circulatory death (4%).
Article Synopsis
- HPV significantly contributes to cancer by causing DNA damage and genome instability, which, along with oxidative stress, plays a key role in tumor development.
- * Oxidative stress intensifies the carcinogenic effects of HPV by enhancing the integration of HPV into the host genome and increasing the expression of viral proteins E6 and E7.
- * Lifestyle factors, genetic changes, and oxidative stress management—such as using dietary antioxidants—are vital for preventing and treating HPV-related cancers.
Introduction: Human papillomavirus (HPV) presents a potential threat to the onset of carcinogenesis in the cervix, anogenital regions, and oropharynx. HPV encompasses over 200 types, with at least 12 having the potential to cause cancer, impacting the majority of sexually active individuals. In this current research, we explore the occurrence and spread of HPV genotypes.
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