Publications by authors named "Negar Sardarpour"
Objectives: This study aims to introduce a methodology for identifying medicinal plants that contain effective natural compounds with the most possible synergistic effects to inhibit cancer survival and proliferation in a multi-targeted manner.
Materials And Methods: To select targets, the signaling pathways involved in cancer development were defined from the KEGG database, and the protein-protein interactions (PPIs) of genes within these pathways were investigated using the STRING software. Then 14 proteins with the highest degree were identified as targets.
Article Synopsis
- Gaucher's disease (GD) is a lysosomal storage disorder caused by a deficiency in the glucocerebrosidase enzyme, leading to glucocerebroside buildup due to mutations in the GBA gene.
- The study examined the genotypes of eight patients and three carriers from nine families, utilizing DNA sequencing to identify six mutations in the GBA gene.
- Among the identified mutations, the most common were c.1448 T>C and RecNcil, while three lesser-known mutations (c.1223 C>T, c.1315 A>G, and c.1214 G>C) were also analyzed for their inheritance patterns.