Ultrasound-assisted magnetic dispersive micro-solid-phase extraction based on carbon quantum dots/zeolite imidazolate framework-90/polyvinyl pyrrolidone/FeO followed by high-performance liquid chromatography with ultraviolet detection for trace analysis of paracetamol and etodolac in human plasma.

A four-part and sustainable nanocomposite composed of carbon quantum dots modified with zeolite imidazolate framework-90, polyvinyl pyrrolidone and magnetite (CQDs/ZIF-90/PVP/FeO) was fabricated and applied in ultrasound-assisted magnetic dispersive micro-solid-phase extraction (US-A-MDMSPE). US-A-MDMSPE was followed by high-performance liquid chromatography with ultraviolet detection (HPLC-UV) for extraction, enrichment and simultaneous low-level monitoring of paracetamol (PCM) and etodolac (EDL) in human plasma. To increase the extraction yield and improve the sensitivity, nanohybrid arrays of metal-organic frameworks and conductive polymers were immobilized on the surface of CQDs followed by magnetization.