Gastroprotective effects of both aqueous and ethanolic extracts of leaves against indomethacin-induced gastric ulcer in rats.

Objectives: Regarding gastroprotective effects, we investigated the protective effects of extracts on reducing gastric ulcer induced by indomethacin.

Materials And Methods: Rats received aqueous and ethanolic extracts of (50, 100, and 200 mg/kg), zileuton (100 mg/kg), montelukast (10 mg/kg), or 1% Tween 80 in presence or absence of indomethacin (100 mg/kg).

Results: Indomethacin produced stomach ulcer and increased neutrophils percentage and MDA level compared with the control group (0.