Publications by authors named "Negar Heidari"
For the first time, a novel simple label-free electrochemical immunosensor was fabricated for sensitive detection of the coat protein of beet necrotic yellow vein virus (CP-BNYVV) as the causal agent of Rhizomania disease in sugar beet. To boost the amplification of the electrochemical signal, gold nanoparticles-reduced graphene oxide (AuNPs-rGO) nanocomposite was employed to modify the glassy carbon electrode. Anti-BNYVV polyclonal was immobilized onto a modified electrode by applying a thiol linker via a self-assembly monolayer (SAM) and activating the functionalized surface using (3-aminopropyl triethoxysilane) and glutaraldehyde.
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- The study focuses on improving early detection and treatment of osteosarcoma (OS) by examining circulating miRNAs as a non-invasive diagnostic tool.
- Utilizing RNAseq and PCR Array data, researchers identified 43 significantly expressed miRNAs and developed a diagnostic model based on four specific miRNAs, showing high accuracy in distinguishing OS patients from healthy individuals.
- The research reveals that the down-regulation of these miRNAs is linked to poor prognosis and lower survival rates, indicating their potential role as tumor suppressors and establishing connections to key cancer-related signaling pathways, paving the way for future therapeutic strategies.
Machine learning and experimental analyses identified miRNA expression models associated with metastatic osteosarcoma.
Biochim Biophys Acta Mol Basis Dis
October 2024
Osteosarcoma (OS), as the most common primary bone cancer, has a high invasiveness and metastatic potential, therefore, it has a poor prognosis. This study identified early diagnostic biomarkers using miRNA expression profiles associated with osteosarcoma metastasis. In the first step, we used RNA-seq and online microarray data from osteosarcoma tissues and cell lines to identify differentially expressed miRNAs.
View Article and Find Full Text PDFAtrial septal defects (ASDs) are common in neonates. Although past studies suggest ASDs ≥ 3 mm in term neonates (TNs) are less likely to close, there is paucity of data regarding the natural history in preterm neonates (PNs), information that would inform surveillance. We sought to compare spontaneous closure rates and need for intervention for ASDs in TNs/near term (≥ 36 weeks) versus PNs (< 36 weeks).
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- As blood oxygen levels drop (hypoxemia), mammals adjust their breathing and heart functions to supply oxygen to critical organs, primarily using carotid bodies as sensors.
- New research highlights that spinal thoracic sympathetic preganglionic neurons act as additional oxygen sensors, responding to low oxygen levels and influencing respiratory and cardiovascular activity even when traditional sensors are absent.
- These spinal oxygen sensors utilize a specific mechanism involving neuronal nitric oxide synthase 1 (NOS1) and NADPH oxidase (NOX), which plays a crucial role in managing the body's response to low oxygen situations and could have implications for various health conditions and crises.
The adsorption of H2Se molecule on AlN-NCS and AlP-NCS surfaces were investigated by using of DFT calculations. The potentials of Cl-functionalized AlN-NCS and AlP-NCS for H2Se adsorption were examined. All processes of H2Se-adsorption on considered nanocone sheets were exothermic reactions.
View Article and Find Full Text PDFRationale: Some investigations have shown that the glutamate receptors play a critical role in cognitive processes such as learning and anxiety.
Objectives: The possible involvement of the cholinergic system of the dorsal hippocampus in the anxiolytic-like response induced by MK-801, NMDA receptor antagonist, was investigated in the present study.
Methods: Male Wistar rats were used in the elevated plus maze apparatus to test the parameters: open arm time (%OAT), open arm entries (%OAE), close arm time (%CAT), close arm entries (%CAE) and other exploratory behaviors (locomotor activity, grooming, rearing and defecation) of anxiety-like response.