Publications by authors named "Neeva Young"
Background: Emerging artemisinin partial resistance and diagnostic resistance are a threat to malaria control in Africa. Plasmodium falciparum kelch13 (k13) propeller-domain mutations that confer artemisinin partial resistance have emerged in Africa. k13-561H was initially described at a frequency of 7.
View Article and Find Full Text PDFArticle Synopsis
- The first detection of the K13 artemisinin resistance mutation 561H occurred in Rwanda, highlighting the need for ongoing surveillance in East Africa as new mutations emerge.
- A study involved collecting malaria-positive samples from 39 health facilities across Rwanda, Uganda, Tanzania, and the DRC, revealing high frequencies of mutations 561H and 675V in Rwanda, indicating significant resistance levels.
- The presence of candidate mutations, alongside other known resistance markers, suggests a concerning trend of increasing drug resistance in the region, potentially threatening malaria treatment effectiveness.
Article Synopsis
- Malaria is a significant health issue in sub-Saharan Africa, with asymptomatic infections contributing to ongoing transmission challenges, especially as non-falciparum malaria becomes more prevalent.
- A study in Rwanda analyzed 4,596 individuals using quantitative PCR and found a 23.6% overall malaria infection rate, with asymptomatic falciparum malaria being widespread and low mixed-species infections common.
- The findings highlight the need for ongoing monitoring of malaria species, emphasizing the connection between falciparum infections and factors like socio-economic status and location.
Background: Emerging artemisinin resistance and diagnostic resistance are a threat to malaria control in Africa. kelch13 (K13) propeller-domain mutations that confer artemisinin partial resistance have emerged in Africa. K13-561H was initially described at a frequency of 7.
View Article and Find Full Text PDF