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4 1 0 1 MCID_676f085e96cd98baec09edf8
39425707
Neetika Srivastava[author] Srivastava, Neetika[Full Author Name] srivastava, neetika[Author]
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39425707 2024 10 25 1097-6779 2024 Oct 18 Gastrointestinal endoscopy Gastrointest Endosc Quality measures in the delivery of equitable endoscopic care to traditionally underserved patients in the United States. S0016-5107(24)03325-X 10.1016/j.gie.2024.06.030 ASGE Quality Assurance in Endoscopy Committee Williams Kathy N KN Division of Gastroenterology, Cooper University Hospital, Camden, New Jersey, USA. May Folasade P FP Vatche and Tamar Manoukian Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, USA. Cummings Linda C LC Division of Gastroenterology and Liver Disease, University Hospitals Cleveland, Cleveland, Ohio, USA. Srivastava Neetika N Division of Gastroenterology and Hepatology, Harbor-UCLA Medical Center, Los Angeles, California, USA. Shahidi Neal N Division of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada. Kohansal Ali A Division of Digestive Care and Endoscopy, Dalhousie University, Halifax, Nova Scotia, Canada. Panganamamula Kashyap K Division of Gastroenterology and Hepatology, Penn Medicine, Philadelphia, Pennsylvania, USA. Garg Rajat R Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA. Singh Amandeep A Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA. Green Bryan B Digestive Disease Group, PA, Greenville, South Carolina, USA. Nguyen Jennie C JC Digestive Diseases Center, MUSC Health, Charleston, South Carolina, USA. Essex Eden A EA American Society for Gastrointestinal Endoscopy, Downers Grove, Illinois, USA. Carethers John M JM Division of Gastroenterology and Hepatology, Moores Cancer Center, and Wetheim School of Public Health, University of California San Diego, San Diego, California, USA. Elmunzer B Joseph BJ Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina, USA. eng Journal Article Practice Guideline 2024 10 18 United States Gastrointest Endosc 0010505 0016-5107 IM Disclosure All authors disclosed no financial relationships. 2024 6 19 2024 6 21 2024 10 19 14 17 2024 10 19 14 17 2024 10 19 10 28 aheadofprint 39425707 10.1016/j.gie.2024.06.030 S0016-5107(24)03325-X 38946853 2024 07 02 1948-5190 16 6 2024 Jun 16 World journal of gastrointestinal endoscopy World J Gastrointest Endosc Long-term impact of artificial intelligence on colorectal adenoma detection in high-risk colonoscopy. 335 342 335-342 10.4253/wjge.v16.i6.335 Improved adenoma detection rate (ADR) has been demonstrated with artificial intelligence (AI)-assisted colonoscopy. However, data on the real-world application of AI and its effect on colorectal cancer (CRC) screening outcomes is limited. To analyze the long-term impact of AI on a diverse at-risk patient population undergoing diagnostic colonoscopy for positive CRC screening tests or symptoms. AI software (GI Genius, Medtronic) was implemented into the standard procedure protocol in November 2022. Data was collected on patient demographics, procedure indication, polyp size, location, and pathology. CRC screening outcomes were evaluated before and at different intervals after AI introduction with one year of follow-up. We evaluated 1008 colonoscopies (278 pre-AI, 255 early post-AI, 285 established post-AI, and 190 late post-AI). The ADR was 38.1% pre-AI, 42.0% early post-AI (P = 0.77), 40.0% established post-AI (P = 0.44), and 39.5% late post-AI (P = 0.77). There were no significant differences in polyp detection rate (PDR, baseline 59.7%), advanced ADR (baseline 16.2%), and non-neoplastic PDR (baseline 30.0%) before and after AI introduction. In patients with an increased pre-test probability of having an abnormal colonoscopy, the current generation of AI did not yield enhanced CRC screening metrics over high-quality colonoscopy. Although the potential of AI in colonoscopy is undisputed, current AI technology may not universally elevate screening metrics across all situations and patient populations. Future studies that analyze different AI systems across various patient populations are needed to determine the most effective role of AI in optimizing CRC screening in clinical practice. ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. Chow Kenneth W KW Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, United States. kwchow555@gmail.com. Bell Matthew T MT Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, United States. Cumpian Nicholas N Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, United States. Amour Maryanne M Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, United States. Hsu Ryan H RH Department of Bioengineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA 92093, United States. Eysselein Viktor E VE Department of Gastroenterology, Harbor-UCLA Medical Center, Torrance, CA 90502, United States. Srivastava Neetika N Department of Gastroenterology, Harbor-UCLA Medical Center, Torrance, CA 90502, United States. Fleischman Michael W MW Department of Gastroenterology, Harbor-UCLA Medical Center, Torrance, CA 90502, United States. Reicher Sofiya S Department of Gastroenterology, Harbor-UCLA Medical Center, Torrance, CA 90502, United States. eng Journal Article United States World J Gastrointest Endosc 101532474 Adenoma detection rate Artificial intelligence Colonoscopy Colorectal adenoma Screening Conflict-of-interest statement: Sofiya Reicher has served as a consultant for Boston Scientific. The rest of the authors have no conflicts of interest to disclose. 2024 2 28 2024 4 16 2024 4 28 2024 7 1 6 43 2024 7 1 6 42 2024 7 1 5 36 2024 6 16 ppublish 38946853 PMC11212514 10.4253/wjge.v16.i6.335 Zhang J, Chen G, Li Z, Zhang P, Li X, Gan D, Cao X, Du H, Zhang J, Zhang L, Ye Y. Colonoscopic screening is associated with reduced Colorectal Cancer incidence and mortality: a systematic review and meta-analysis. J Cancer. 2020;11:5953–5970. PMC7477408 32922537 Ahn SB, Han DS, Bae JH, Byun TJ, Kim JP, Eun CS. The Miss Rate for Colorectal Adenoma Determined by Quality-Adjusted, Back-to-Back Colonoscopies. Gut Liver. 2012;6:64–70. PMC3286741 22375173 Schottinger JE, Jensen CD, Ghai NR, Chubak J, Lee JK, Kamineni A, Halm EA, Sugg-Skinner C, Udaltsova N, Zhao WK, Ziebell RA, Contreras R, Kim EJ, Fireman BH, Quesenberry CP, Corley DA. Association of Physician Adenoma Detection Rates With Postcolonoscopy Colorectal Cancer. JAMA. 2022;327:2114–2122. PMC9175074 35670788 Kaminski MF, Wieszczy P, Rupinski M, Wojciechowska U, Didkowska J, Kraszewska E, Kobiela J, Franczyk R, Rupinska M, Kocot B, Chaber-Ciopinska A, Pachlewski J, Polkowski M, Regula J. Increased Rate of Adenoma Detection Associates With Reduced Risk of Colorectal Cancer and Death. Gastroenterology. 2017;153:98–105. 28428142 Xu H, Tang RSY, Lam TYT, Zhao G, Lau JYW, Liu Y, Wu Q, Rong L, Xu W, Li X, Wong SH, Cai S, Wang J, Liu G, Ma T, Liang X, Mak JWY, Xu H, Yuan P, Cao T, Li F, Ye Z, Shutian Z, Sung JJY. Artificial Intelligence-Assisted Colonoscopy for Colorectal Cancer Screening: A Multicenter Randomized Controlled Trial. Clin Gastroenterol Hepatol. 2023;21:337–346. 35863686 Hassan C, Spadaccini M, Iannone A, Maselli R, Jovani M, Chandrasekar VT, Antonelli G, Yu H, Areia M, Dinis-Ribeiro M, Bhandari P, Sharma P, Rex DK, Rösch T, Wallace M, Repici A. Performance of artificial intelligence in colonoscopy for adenoma and polyp detection: a systematic review and meta-analysis. Gastrointest Endosc. 2021;93:77–85. 32598963 Chan HP, Hadjiiski LM, Samala RK. Computer-aided diagnosis in the era of deep learning. Med Phys. 2020;47:e218–e227. PMC7293164 32418340 Gupta S, Lieberman D, Anderson JC, Burke CA, Dominitz JA, Kaltenbach T, Robertson DJ, Shaukat A, Syngal S, Rex DK. Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer. Gastrointest Endosc. 2020;91:463–485. PMC7389642 32044106 Repici A, Badalamenti M, Maselli R, Correale L, Radaelli F, Rondonotti E, Ferrara E, Spadaccini M, Alkandari A, Fugazza A, Anderloni A, Galtieri PA, Pellegatta G, Carrara S, Di Leo M, Craviotto V, Lamonaca L, Lorenzetti R, Andrealli A, Antonelli G, Wallace M, Sharma P, Rosch T, Hassan C. Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Randomized Trial. Gastroenterology. 2020;159:512–520. 32371116 Repici A, Spadaccini M, Antonelli G, Correale L, Maselli R, Galtieri PA, Pellegatta G, Capogreco A, Milluzzo SM, Lollo G, Di Paolo D, Badalamenti M, Ferrara E, Fugazza A, Carrara S, Anderloni A, Rondonotti E, Amato A, De Gottardi A, Spada C, Radaelli F, Savevski V, Wallace MB, Sharma P, Rösch T, Hassan C. Artificial intelligence and colonoscopy experience: lessons from two randomised trials. Gut. 2022;71:757–765. 34187845 Ladabaum U, Shepard J, Weng Y, Desai M, Singer SJ, Mannalithara A. Computer-aided Detection of Polyps Does Not Improve Colonoscopist Performance in a Pragmatic Implementation Trial. Gastroenterology. 2023;164:481–483. 36528131 Levy I, Bruckmayer L, Klang E, Ben-Horin S, Kopylov U. Artificial Intelligence-Aided Colonoscopy Does Not Increase Adenoma Detection Rate in Routine Clinical Practice. Am J Gastroenterol. 2022;117:1871–1873. 36001408 Cai C, Gaffney A, McGregor A, Woolhandler S, Himmelstein DU, McCormick D, Dickman SL. Racial and Ethnic Disparities in Outpatient Visit Rates Across 29 Specialties. JAMA Intern Med. 2021;181:1525–1527. PMC8290333 34279566 Almario CV, May FP, Ponce NA, Spiegel BM. Racial and Ethnic Disparities in Colonoscopic Examination of Individuals With a Family History of Colorectal Cancer. Clin Gastroenterol Hepatol. 2015;13:1487–1495. PMC4509986 25737445 Zavala VA, Bracci PM, Carethers JM, Carvajal-Carmona L, Coggins NB, Cruz-Correa MR, Davis M, de Smith AJ, Dutil J, Figueiredo JC, Fox R, Graves KD, Gomez SL, Llera A, Neuhausen SL, Newman L, Nguyen T, Palmer JR, Palmer NR, Pérez-Stable EJ, Piawah S, Rodriquez EJ, Sanabria-Salas MC, Schmit SL, Serrano-Gomez SJ, Stern MC, Weitzel J, Yang JJ, Zabaleta J, Ziv E, Fejerman L. Cancer health disparities in racial/ethnic minorities in the United States. Br J Cancer. 2021;124:315–332. PMC7852513 32901135 Rex DK, Schoenfeld PS, Cohen J, Pike IM, Adler DG, Fennerty MB, Lieb JG 2nd, Park WG, Rizk MK, Sawhney MS, Shaheen NJ, Wani S, Weinberg DS. Quality indicators for colonoscopy. Am J Gastroenterol. 2015;110:72–90. 25448873 Gong D, Wu L, Zhang J, Mu G, Shen L, Liu J, Wang Z, Zhou W, An P, Huang X, Jiang X, Li Y, Wan X, Hu S, Chen Y, Hu X, Xu Y, Zhu X, Li S, Yao L, He X, Chen D, Huang L, Wei X, Wang X, Yu H. Detection of colorectal adenomas with a real-time computer-aided system (ENDOANGEL): a randomised controlled study. Lancet Gastroenterol Hepatol. 2020;5:352–361. 31981518 Su JR, Li Z, Shao XJ, Ji CR, Ji R, Zhou RC, Li GC, Liu GQ, He YS, Zuo XL, Li YQ. Impact of a real-time automatic quality control system on colorectal polyp and adenoma detection: a prospective randomized controlled study (with videos) Gastrointest Endosc. 2020;91:415–424. 31454493 Wang P, Berzin TM, Glissen Brown JR, Bharadwaj S, Becq A, Xiao X, Liu P, Li L, Song Y, Zhang D, Li Y, Xu G, Tu M, Liu X. Real-time automatic detection system increases colonoscopic polyp and adenoma detection rates: a prospective randomised controlled study. Gut. 2019;68:1813–1819. PMC6839720 30814121 Wang P, Liu X, Berzin TM, Glissen Brown JR, Liu P, Zhou C, Lei L, Li L, Guo Z, Lei S, Xiong F, Wang H, Song Y, Pan Y, Zhou G. Effect of a deep-learning computer-aided detection system on adenoma detection during colonoscopy (CADe-DB trial): a double-blind randomised study. Lancet Gastroenterol Hepatol. 2020;5:343–351. 31981517 Mangas-Sanjuan C, de-Castro L, Cubiella J, Díez-Redondo P, Suárez A, Pellisé M, Fernández N, Zarraquiños S, Núñez-Rodríguez H, Álvarez-García V, Ortiz O, Sala-Miquel N, Zapater P, Jover R CADILLAC study investigators. Role of Artificial Intelligence in Colonoscopy Detection of Advanced Neoplasias : A Randomized Trial. Ann Intern Med. 2023;176:1145–1152. 37639723 Dilmaghani S, Coelho-prabhu N. Role of Artificial Intelligence in Colonoscopy: A Literature Review of the Past, Present, and Future Directions. TIGE. 2023;25:399–412. Hsieh YH, Tang CP, Tseng CW, Lin TL, Leung FW. Computer-Aided Detection False Positives in Colonoscopy. Diagnostics (Basel) 2021;11 PMC8235696 34207226 26659548 2016 09 12 2016 01 21 1477-0539 14 4 2016 Jan 28 Organic & biomolecular chemistry Org Biomol Chem Identification of gallic acid based glycoconjugates as a novel tubulin polymerization inhibitors. 1338 1358 1338-58 10.1039/c5ob02113h A novel class of gallic acid based glycoconjugates were designed and synthesized as potential anticancer agents. Among all the compounds screened, compound 2a showed potent anticancer activity against breast cancer cells. The latter resulted in tubulin polymerization inhibition and induced G2/M cell cycle arrest, generation of reactive oxygen species, mitochondrial depolarization and subsequent apoptosis in breast cancer cells. In addition, ultraviolet-visible spectroscopy and fluorescence quenching studies of the compound with tubulin confirmed direct interaction of compounds with tubulin. Molecular modeling studies revealed that it binds at the colchicine binding site in tubulin. Further, 2a also exhibited potent in vivo anticancer activity in LA-7 syngeneic rat mammary tumor model. Current data projects its strong candidature to be developed as anticancer agent. Upadhyaya Kapil K Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute (CSIR-CDRI), Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. rpt.cdri@gmail.com rp_tripathi@cdri.res.in. Hamidullah Singh Kartikey K Arun Ashutosh A Shukla Mahendra M Srivastava Neetika N Ashraf Raghib R Sharma Abhisheak A Mahar Rohit R Shukla Sanjeev K SK Sarkar Jayanta J Ramachandran Ravishankar R Lal Jawahar J Konwar Rituraj R Tripathi Rama Pati RP eng Journal Article Research Support, Non-U.S. Gov't 2015 12 11 England Org Biomol Chem 101154995 1477-0520 0 Antineoplastic Agents 0 Glycoconjugates 0 Reactive Oxygen Species 0 Tubulin 0 Tubulin Modulators 632XD903SP Gallic Acid IM Animals Antineoplastic Agents chemical synthesis chemistry pharmacology Apoptosis drug effects Cell Cycle drug effects Cell Proliferation drug effects Disease Models, Animal Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Female Gallic Acid chemistry pharmacology Glycoconjugates chemical synthesis chemistry pharmacology Humans Mammary Neoplasms, Experimental drug therapy pathology Mice Polymerization drug effects Rats Reactive Oxygen Species metabolism Structure-Activity Relationship Tubulin metabolism Tubulin Modulators chemical synthesis chemistry pharmacology Tumor Cells, Cultured 2015 12 15 6 0 2015 12 15 6 0 2016 9 13 6 0 ppublish 26659548 10.1039/c5ob02113h 17720911 2008 04 30 2018 11 13 0016-6731 177 2 2007 Oct Genetics Genetics Genomewide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X chromosome and autosomes. 689 697 689-97 Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the autosomes. Call Gerald B GB Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095, USA. 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Publications by Neetika Srivastava | LitMetric
Publications by authors named "Neetika Srivastava"
World J Gastrointest Endosc
June 2024
Background : Improved adenoma detection rate (ADR) has been demonstrated with artificial intelligence (AI)-assisted colonoscopy. However, data on the real-world application of AI and its effect on colorectal cancer (CRC) screening outcomes is limited.Aim : To analyze the long-term impact of AI on a diverse at-risk patient population undergoing diagnostic colonoscopy for positive CRC screening tests or symptoms.
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Org Biomol Chem
January 2016
A novel class of gallic acid based glycoconjugates were designed and synthesized as potential anticancer agents. Among all the compounds screened, compound 2a showed potent anticancer activity against breast cancer cells. The latter resulted in tubulin polymerization inhibition and induced G2/M cell cycle arrest, generation of reactive oxygen species, mitochondrial depolarization and subsequent apoptosis in breast cancer cells.
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Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the autosomes.
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