Osteogenic Sarcoma Presenting with Skip, Lymph Nodal, Pulmonary, Pleural Metastases and Malignant Effusion: An Unusual Appearance on Bone Scan.

Osteogenic sarcoma is an aggressive malignant bone tumor arising from primitive mesenchymal bone-forming cells. Ossification is the characteristic feature of the metastases in osteosarcoma which aids their detection on Tc-MDP bone scintigraphy. Although lung is the most common site of metastasis in osteogenic sarcoma, pleural involvement with effusion and skip metastases are rare.

Efficacy and safety of 177Lu-DOTMP in palliative treatment of symptomatic skeletal metastases: a prospective study.

Aims: Bone-seeking radiopharmaceutical 177Lu-DOTMP with favorable pharmacokinetics in the preclinical studies has been evaluated for its role in reducing bone pain and improving quality of life (QOL) in patients with symptomatic skeletal metastases.

Method: Patients with painful widespread skeletal metastases documented on 99mTc-MDP bone scintigraphy were intravenously administered 37 MBq/kg of 177Lu-DOTMP. Visual analogue score (VAS), analgesic score, European Cooperative Group of Oncology (ECOG) and the European Organization of Research and Treatment of Cancer QLQ-C30 of all the patients were assessed at baseline and posttherapy follow-up.

Association of use of proton pump inhibitors and H antagonists with stomach wall uptake in Tc-methoxy-isobutyl-isonitrile (MIBI) myocardial perfusion imaging.

Background: Stomach wall uptake (SWU) of tracer in Tc-MIBI myocardial perfusion imaging (MPI) occasionally leads to imaging artifacts, thereby lowering the diagnostic accuracy. It is less-studied phenomenon for possible link with proton pump inhibitors (PPIs) intake. This prospective work looked for association of SWU with PPI intake and compared its incidence with H antagonists (HA) users and patients not on either gastroprotective medication.

Orbital Metastasis: Rare Initial Presentation of an Occult Gall Bladder Carcinoma.

Orbital metastases are known to arise from primary breast carcinoma followed by prostate, malignant melanoma, and lung carcinoma. We report a case of orbital metastasis as the initial presentation of an occult primary gall bladder carcinoma. The FDG PET/CT helped in localizing the occult distant primary site, which previously escaped detection, and also enabled the evaluation of orbital metastasis.