Publications by authors named "Neelima Katam"
Article Synopsis
- Invasive cervical cancer (ICC) is preventable and can be detected early through screening, but women living with HIV often present at advanced stages, leading to higher mortality rates.
- A cohort study in Nigeria enrolled 239 women with confirmed ICC, assessing their HIV status, stages of cancer, and overall survival through various analytical methods.
- Results showed that HIV-positive patients were generally younger, had more advanced stages of ICC at diagnosis, and experienced lower overall survival rates compared to HIV-negative patients.
Article Synopsis
- Invasive cervical cancer (ICC) is increasingly prevalent among women with HIV in Nigeria, emphasizing the importance of early detection and treatment to reduce mortality rates associated with advanced stages of the disease.
- A cohort study conducted in two Nigerian hospitals enrolled 239 women diagnosed with ICC, revealing significant differences in age, cancer staging, and survival outcomes between HIV-positive and HIV-negative patients.
- Results indicated that HIV-positive women were younger and presented with more advanced cancer stages, resulting in lower overall survival rates compared to their HIV-negative counterparts.
Purpose: Circulating tumor DNA (ctDNA) has emerged as a promising noninvasive biomarker for baseline characterization and longitudinal monitoring of a tumor throughout disease management. The aim of this study was to evaluate the utility of ctDNA across a wide spectrum of tumor types.
Methods: We retrospectively identified 1,763 patients with advanced cancers who had next-generation sequencing of ctDNA or tumor tissue completed by a designated commercial assay at Northwestern University.
Patients with a history of malignancy have been shown to be at an increased risk of COVID-19-related morbidity and mortality. Poorer clinical outcomes in that patient population are likely due to the underlying systemic illness, comorbidities, and the cytotoxic and immunosuppressive anti-tumor treatments they are subjected to. We identified 416 cancer patients with SARS-CoV-2 infection being managed for their malignancy at Northwestern Medicine in Chicago, Illinois, between March and July of 2020.
View Article and Find Full Text PDFBackground: The correlation of ERBB2 copy number gain (CNG) from tissue or circulating tumor DNA (ctDNA) by next-generation sequencing (NGS) with standard HER2 tissue evaluation is not well understood.
Materials And Methods: We retrospectively identified patients with ERBB2 CNG on commercial NGS. We described their clinical-pathologic features and calculated the positive predictive value (PPV) of ERBB2 CNG by NGS for HER2-positivity by IHC and FISH testing.
Purpose: Circulating tumor DNA (ctDNA) is a promising tool for noninvasive longitudinal monitoring of genomic alterations. We analyzed serial ctDNA to characterize genomic evolution in progressive metastatic breast cancer.
Experimental Design: This was a retrospective cohort between 2015 and 2019 obtained under an Institutional Review Board-approved protocol at Northwestern University (Chicago, IL).
Background: We describe the genomic landscape of circulating tumour DNA (ctDNA) across pathological subtypes of metastatic breast cancer.
Methods: 255 clinically annotated patients with ctDNA testing by Guardant360 were stratified into HR+, HER2+, and TNBC cohorts. Frequency and heterogeneity of alterations were reported.
Semaphorin 7a links nerve regeneration and inflammation in the cornea.
Invest Ophthalmol Vis Sci
July 2012
Purpose: We determined Semaphorin 7a (Sema7a) localization and abundance in naive corneas and in corneas after nerve-transecting lamellar flap surgery, and determined the effect of Sema7a supplementation on corneal nerve regeneration and inflammation.
Methods: Immunolocalization and Western blot analyses were performed to evaluate the abundance of Sema7a in naive corneas and corneas undergoing nerve regeneration after lamellar corneal surgery in thy1-YFP+ neurofluorescent mice. We used compartmental cultures of dissociated trigeminal ganglion cells to determine the effect of Sema7a exposure on neurite outgrowth in vitro.