Molecular docking analysis of shatavarins with female hormonal receptors.

Shatavari () has been used for female health problems since ancient times and is useful for treating various female reproductive problems including menopausal problems, hormonal imbalance, lactation, menstrual issues, and others. Shatavarins, the primary phytoconstituents of Shatavari, have high molecular weights and may interact with hormone receptors. We have conducted a molecular docking analysis for different Shatavarins such as Shatavarin I, Shatavarin IV, Shatavarin VI, Shatavarin VII, Shatavarin VIII, Shatavarin IX, and Shatavarin X with different hormonal receptors such as estrogen alpha, beta, and gamma receptor, progesterone receptor, FSH, and LH receptors.

Computational approach for elucidating interactions of cross-species miRNAs and their targets in Flaviviruses.

Background & Objectives: Combating viral diseases has been a challenging task since time immemorial. Available molecular approaches are limited and not much effective for this daunting task. MicroRNA based therapies have shown promise in recent times.

A Complex Network of MicroRNAs Expressed in Brain and Genes Associated with Amyotrophic Lateral Sclerosis.

Amyotrophic Lateral Sclerosis (ALS) is a rare neurological disease affecting mainly motor neurons and often leads to paralysis and death in extreme cases. For exploring the role of microRNAs in genes regulation in ALS disease, miRanda was employed for prediction of target sites of miRNAs expressed in various parts of brain and CNS on 35 genes associated with ALS. Similar search was conducted using TargetScan and PicTar for prediction of target sites in 3' UTR only.

Analyzing a Potential Drug Target N-Myristoyltransferase of Plasmodium falciparum Through In Silico Approaches.

Background: Despite concerted global efforts to combat malaria, malaria elimination is still a remote dream. Fast evolution rate of malarial parasite along with its ability to respond quickly to any drug resulting in partial or complete resistance has been a cause of concern among researcher communities.

Materials And Methods: Molecular modeling approach was adopted to gain insight about the structure and various analyses were performed.

In silico characterization of Shikimate Kinase of Shigella flexneri: a potential drug target.

Shigella flexneri is a major pathogen responsible for Shigellosis causing massive morbidity among young population and imposes huge socio-economic burden. In this study, Shikimate Kinase (SK) from S. flexneri was characterized in silico and disordered regions were predicted.

Application of Kohonen maps for solving the classification puzzle in AGC kinase protein sequences.

Availability of enormous number of sequences in public domain databases warrants the need for effective tools for clustering and classification of such data. AGC protein kinase family is known to contain many enzymes involved in important cellular processes. In the present study, 21 important physicochemical parameters were calculated for 115 sequences of AGC kinase family belonging to mouse and human.

Interaction map and selection of microRNA targets in Parkinson's disease-related genes.

Parkinson's disease (PD) is a complex multigenic neurodisorder frequently occurring in elderly persons. To investigate noncoding tiny microRNA mediated gene regulation, miRanda (version 1.0b) was used to predict human miRNA target sites on selected 29 genes related to PD.

Comparative characterization of commercially important xylanase enzymes.

Xylanase is an industrially important enzyme having wide range of applications especially in paper industry. It is crucial to gain an understanding about the structure and functional aspects of various xylanases produced from diverse sources. In this study, a bioinformatics and molecular modeling approach was adopted to explore properties and structure of xylanases.

Structural model of the Plasmodium falciparum thioredoxin reductase:a novel target for antimalarial drugs.

Background: Malaria, a scourge of mankind, imposes a huge socioeconomic burden in tropical countries. Emergence of multi-drug resistant malarial parasites impels us to explore novel drug targets. Thioredoxin reductase is a promising antimalarial drug target.

Database management system for the control of malaria in Arunachal Pradesh, India.

Unlabelled: The Arunachal Pradesh state in India is epidemic for malaria, caused by P.vivax and P.falciparum.