Publications by authors named "Neeli Mishra"
Article Synopsis
- Action segmentation involves labeling each frame in behavioral videos, essential for studying animal behavior across various species.
- A variety of algorithms, including supervised, unsupervised, and semi-supervised learning methods, are evaluated for their effectiveness in identifying discrete animal behaviors.
- The study introduces a new semi-supervised model, finding that fully supervised temporal convolutional networks, enhanced with temporal information, yield the highest performance on supervised metrics across different datasets.
Article Synopsis
- Researchers used advanced SCAPE microscopy to observe neurons in the brains of adult fruit flies, capturing detailed images while the flies exhibited various natural behaviors.
- They found that most neurons showed activity patterns closely linked to running and flailing movements over seconds to a minute, while responses to grooming were less pronounced.
- The study also identified high-dimensional residual activity among small groups of organized neurons, which may correspond to specific genetic types, indicating that local microcircuits work within a broader neural context.
Optogenetics allows the manipulation of neural activity in freely moving animals with millisecond precision, but its application in Drosophila melanogaster has been limited. Here we show that a recently described red activatable channelrhodopsin (ReaChR) permits control of complex behavior in freely moving adult flies, at wavelengths that are not thought to interfere with normal visual function. This tool affords the opportunity to control neural activity over a broad dynamic range of stimulation intensities.
View Article and Find Full Text PDFTranscriptional states are formed and maintained by the interaction and post-translational modification (PTM) of several chromatin proteins, such as histones and high mobility group (HMG) proteins. Among these, HMGA1a, a small heterochromatin-associated nuclear protein has been shown to be post-translationally modified, and some of these PTMs have been linked to apoptosis and cancer. In cancerous cells, HMGA1a PTMs differ between metastatic and nonmetastatic cells, suggesting the existence of an HMGA1a PTM code analogous to the "histone code.
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