Publications by authors named "Neelam Z Mukherjee"
Cancer Immunol Res
March 2019
Article Synopsis
- mTOR plays a key role in regulating tumor growth and T-cell function, which complicates the use of mTOR inhibitors like rapamycin in cancer treatment.
- Preclinical studies show that low doses of rapamycin can enhance T-cell immunity while higher doses suppress tumor growth.
- In a patient study, low-dose rapamycin reduced T-cell exhaustion and improved immune modulation, potentially increasing the effectiveness of immunotherapy after surgery while also being associated with some wound complications.
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