Nanocrystals: A Deep Insight into Formulation Aspects, Stabilization Strategies, and Biomedical Applications.

Background: Drugs with poor solubility exhibit hurdles in their formulation due to poor dissolution and low bioavailability. Nanocrystallization is a great technique for incorporating poorly soluble drugs and is associated with many benefits.

Objective: The objective of the present review is to discuss formulation techniques for the generation of Nanocrystals (NCs) and illustrate the various advantages of NCs.

Synthesis and biological profile of substituted benzimidazoles.

Background: A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities.

Results And Discussion: The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species.

Analgesic, anti-inflammatory and antiulcer activity of nitric oxide releasing ester derivatives of indomethacin.

Analgesic, antiinflammatory and antiulcer activity of newly synthesized nitric oxide (NO) releasing ester derivatives of indomethacin were evaluated in rats. Synthetic compounds (NB-02, NP-02 and NE-02) 6 mg/kg, po each significantly (P < 0.01) increased the tail flick reaction time in rats.