Topical sirolimus as an effective treatment for a deep neurofibroma in a patient with neurofibromatosis type I.

A 14-year-old boy with neurofibromatosis type I (NF1) presented with a painful neurofibroma on his right palm. The lesion was treated with topical sirolimus, resulting in decreased size and pain and improvement in motor function of his hand. This case demonstrates the efficacy of topical sirolimus in the management of neurofibromas in NF1.

Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial.

Aim: To evaluate the effect of sitagliptin placebo on histologic and non-histologic parameters of non-alcoholic steatohepatitis (NASH).

Methods: Twelve patients with biopsy-proven NASH were randomized to sitagliptin (100 mg daily) ( = 6) or placebo ( = 6) for 24 wk. The primary outcome was improvement in liver fibrosis after 24 wk.

Relapsing Polychondritis: A Review and Guide for the Dermatologist.

Relapsing polychondritis, or RP, is a rare connective tissue disease characterized by relapsing-remitting destructive inflammation of the cartilaginous and other proteoglycan-rich structures in the body. Given the relatively low incidence of RP, a concise clinically relevant guide, focusing on the cutaneous manifestations of this serious disease, is lacking. In this review, we provide the dermatologist with an approach to diagnosing RP and a guide to its initial work-up, and management.

Management of non-alcoholic fatty liver disease in 2015.

There is no single pharmacologic therapy that has been approved to treat nonalcoholic fatty liver disease in the general population. The backbone of therapy currently includes intensive lifestyle modification with established targets for diet and weight loss. The use of unsweetened, unfiltered coffee along with limiting high fructose corn syrup have emerged as beneficial dietary recommendations.

Venous thromboprophylaxis in gastrointestinal bleeding.

Objective: To study the use of venous thromboembolism (VTE) prophylaxis and the incidence of thrombotic events in patients with acute gastrointestinal (GI) bleeding.

Methods: Individuals admitted with a primary diagnosis of a GI bleed along with any endoscopically confirmed source (over a two-year period) were included. Patient comorbidity and data regarding anticoagulation or antiplatelet agent use before hospitalization were collected, in addition to type of VTE prophylaxis and duration of treatment.

The pathogenesis of vitiligo.

Background: Vitiligo is a commonly encountered pigmentary disorder. Numerous studies and investigations from all over the world have attempted to determine the mechanisms behind this disease; however, the pathogenesis of vitiligo remains elusive.

Objective: n this comprehensive review article, we present the findings behind the five overarching theories of what causes this disfiguring and psychologically debilitating disease.