Publications by authors named "Neeharika L Mathukumalli"
To report a patient with concomitant aceruloplasminemia (with a novel mutation) and IgG4-related pachymeningitis and to hypothesize on the possible relation between the two diseases. Clinical, radiological, and laboratory features of a 56-year-old lady with chronic headache, bifacial palsy, and cerebellar signs are described. Pathophysiology of aceruloplasminemia leading to hyperferritinemia and consequent immune activation is elucidated.
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- Thymectomy, combined with other treatments like corticosteroids and immunosuppressants, is the standard approach for treating myasthenia gravis (MG), but its specific effects on myasthenic crises were previously unclear.
- A study analyzed 274 patients with generalized myasthenia gravis from a medical institute, comparing outcomes for those who underwent thymectomy versus those who did not, focusing on crisis occurrences and quality of life.
- Results showed that patients who had thymectomy had significantly lower rates of myasthenic crises (25.9%) compared to those without the surgery (53.3%), though both groups reported similar quality of life scores before and after treatment.
Objective: To study impact of COVID-19 pandemic on frequency, clinical/electrophysiological profile and treatment outcomes in pediatric Guillain-Barré syndrome (GBS).
Background: GBS is the most frequent cause of pediatric acute flaccid paralysis. The effect of the COVID-19 pandemic on pediatric GBS is unclear in the literature.
Background: The diagnosis of isolated cortical vein thrombosis (ICVT) involving superficial middle cerebral vein (SMCV) remains challenging even in the present era of modern MRI protocols.
Objective: The purpose of this study is to review the clinical and radiological characteristics of SMCV thrombosis in our hospital.
Methods: Chart review of cases of SMCV thrombosis admitted in a tertiary care university hospital in South India during a 1-year period from September 2015 to August 2016.
Background: Cobalamin deficiency, either due to dietary inadequacy or increased consumption attributable to levodopa-mediated metabolic disturbance, and resultant hyperhomocysteinemia may contribute to peripheral neuropathy (PN) in Parkinson's disease (PD).
Aim: The aim of the study is to assess the prevalence of Vitamin B12 deficiency, hyperhomocysteinemia in Indian PD patients, and their association with PN.
Materials And Methods: Clinical details were collected in 93 patients over a period of 2 years.
Background: Neuromyelitis Optica spectrum disorders (NMOSD) are one of the most common CNS demyelinating disorders as they will present with disabling recurrent demyelinating attacks. Hence, it is of paramount importance to diagnose early, and early diagnoses and intervention will prevent further relapses associated with NMOSD. New international consensus criteria have been proposed and studies validating its application towards diagnoses of NMOSD in south Asian population are meagre.
View Article and Find Full Text PDFWe report an HIV patient aged 38 years with acute inflammatory demyelinating polyradiculoneuropathy subtype of Guillain-Barré syndrome (GBS) as the only manifestation of seroconversion and worsening of GBS being the harbinger of immune reconstitution inflammatory syndrome (IRIS). To date, only 5 cases of GBS during IRIS are reported. They manifested either during the third week or later after starting highly active antiretroviral therapy (HAART).
View Article and Find Full Text PDFBackground: Intrasinus thrombolysis (IST) is believed to improve outcome in patients of cerebral venous sinus thrombosis (CVST) unresponsive to heparin.
Purpose: The purpose of this article is to describe our experience with IST in patients of CVST unresponsive to heparin.
Materials And Methods: Hospital databases were searched, and patients with CVST who underwent IST from May 2011 to March 2014 were identified.