Methylene blue-loaded niosome: preparation, physicochemical characterization, and in vivo wound healing assessment.

Following skin injury, the overproduction of reactive oxygen species (ROS) during the inflammatory phase can cause tissue damage and delay in wound healing. Methylene blue (MB) decreases mitochondrial ROS production and has antioxidant effects. The authors aimed to prepare MB-loaded niosomes using the ultra-sonication technique as a green formulation method.

Preparation, characterization and in vivo evaluation of novel hyaluronan containing niosomes tailored by Box-Behnken design to co-encapsulate curcumin and quercetin.

Designing novel drug delivery systems to improve drug efficiencies have gained great interests in recent years. In this study, a new vesicular system has been prepared using thin film hydration method with slight modifications, hydrophobic drugs have been used in both lipophilic and hydrophilic phases and dry film was hydrated by hyaluronan polymeric solution, to overcome curcumin and quercetin formulation drawbacks. Briefly, different formulations were prepared according to Box-Behnken design to assess the effect of HLB value, cholesterol and hyaluronan contents on the properties of niosomes.

The relationship between quality of life and coping strategies in polycystic ovary syndrome patients.

Background: There are many factors that affect the quality of life, for example, stress and the coping strategies. Polycystic ovary syndrome is a common hormonal disorder leading to menstrual disorders, hirsutism, acne, obesity, infertility and abortion. In such cases, the patients suffer from a variety of stresses and face problems in their coping strategies with life's problems which can affect the quality of life and cause psychological distress and low the quality of life.

A Box-Behnken design for determining the optimum experimental condition of the fungicide (Vapam) sorption onto soil modified with perlite.

In the present study, response surface methodology (RSM) based on the Box-Behnken design (BBD) was employed to investigate the effects of the different operating conditions on the removal of the fungicide (Vapam) onto soil modified with perlite using sorption process. The process parameters such as pH of the fungicide solution (2, 5 and 8), temperature (15, 25 and 35°C), shaking time (2, 13 and 24 h) and the percentage of perlite in the modified soil (0, 2 and 4 %) were investigated using a four-factor-three-level Box-Behnken design at an initial fungicide concentration of C(0) = 1.6 mg/L as a fixed input parameter.

Parameter optimization of the fungicide (Vapam) sorption onto soil modified with clinoptilolite by Taguchi method.

This study employs the Taguchi optimization methodology to optimize the effective parameters for the pesticide (Vapam) sorption onto soil modified with natural zeolite (clinoptilolite). The experimental factors and their ranges chosen for determination of the effective parameters were: initial Vapam concentration (0.4-1.