The effect of co-administration of simvastatin and alcohol in rats.

Introduction: The effect of chronic co-administration of alcohol (Alc) and lipid-lowering drugs on hepatic function has not been extensively evaluated. We studied the effects of administering Alc together with a 3-hydroxy-3 methylglutaryl coenzyme A reductase inhibitor [simvastatin (S)].

Materials And Methods: Male Wistar rats (8 weeks old) were randomized and divided into 4 groups of 10 each.