The association of circulating leptin level with peripheral DNA damage in hemodialysis subjects.

Objectives: Hemodialysis subjects have been shown to have both elevated serum leptin and peripheral DNA damage level, and leptin has been suggested to induce apoptotic features. Thus, in the present study, we aimed at finding out if there is any relationship between serum leptin level and peripheral DNA damage in hemodialysis subjects.

Design And Methods: Forty hemodialysis subjects and 21 controls were included in the present study.

Measurement of the total antioxidant response using a novel automated method in subjects with nonalcoholic steatohepatitis.

Background: Oxidative stress, an increase in oxidants and/or a decrease in antioxidant capacity, is one of the potential biochemical mechanisms involved in the pathogenesis of nonalcoholic steatohepatitis. We aimed to investigate the total antioxidant response using a novel automated method in nonalcoholic steatohepatitis subjects. As a reciprocal measure, we also aimed to determine total peroxide level in the same plasma samples.