Relationship of protein, calcium and vitamin D consumption with body composition and fractures in oldest-old independent people.

Background & Aim: Some studies state that the protein intake has a protective effect against bone mass loss, while others show that the combination of low calcium intake and high protein consumption increases the risk of fractures. Perhaps this phenomenon is also altered by the consumption of vitamin D after the age 80 years. This study aimed to identify if there is an association of protein, calcium and vitamin D intake with body composition and fractures in community dwelling 80 years or older independent people.

Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences.

Background: Epidemiological studies demonstrate an association between diabetes and low neuromuscular strength (NMS). However, none have grouped participants into nondiabetics (ND), undiagnosed diabetics (UDD), controlled diabetics (CD), and uncontrolled diabetics (UCD) or investigated what glycated hemoglobin levels (HbA1c) are associated with low NMS (dynapenia) by sex.

Methods: We analyzed the association between UDD, CD, and UCD and dynapenia, the extent to which the different groupings of these individuals modifies this association and the association between HbA1c levels and NMS, by sex, in a cross-sectional study involving 5,290 participants ≥50 years from the ELSA study.

In vitro cytotoxicity of fenthion and related metabolites in human neuroblastoma cell lines.

The aim of our research was the evaluation in vitro of the neurotoxic effects of fenthion and its metabolites on human neuroblastoma cells, as a model for their toxicity in humans. The results indicate that 24 hours exposure was sufficient to produce dose related effects on SK-N-BE and IMR 32 cell viability causing detachment and loss of cells at the effective doses. In the two cell lines fenthion metabolites display an increased cytotoxicity respect to the parent compound with a distinct pattern of toxicity on neurons.