Publications by authors named "Nebojsa Stojanovic"

Both inside data centers (DCs) and in short optical links between data centers (DC campuses), intensity-modulation and direct-detection (IMDD) systems using four-level pulse amplitude modulation (PAM4) will dominate this decade due to low transceiver price and power consumption. The next DC transceiver generation based on 100 Gbaud PAM4 will require advanced digital signal processing (DSP) algorithms and more powerful forward error correction (FEC) codes. Because of bandwidth limitations, the conventional DC DSP based on a few-tap linear feed-forward equalizer (FFE) is likely to be upgraded to more complex but still low-complexity Volterra equalizers followed by a noise whitening filter and either a maximum likelihood sequence estimation (MLSE) or a maximum a posteriori probability (MAP) algorithm.

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Article Synopsis
  • This study showcases experimental findings on different modulation and coding techniques for 200 Gb/s intensity modulation and direct detection links.
  • It compares four-level pulse amplitude modulation (PAM-4), PAM-6, trellis-coded modulation (TCM), and discrete multi-tone (DMT) transmission.
  • The research utilizes advanced commercial components with a focus on C-band Mach-Zehnder modulators and O-band electro-absorption modulated laser transmitters for intra-data center applications.
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Neurocysticercosis is the most common parasitic disease of the nervous system, nevertheless, it can remain undetected for a long period of time, especially if it occurs in non endemic areas and regions with low-endemicity. Inadequate diagnostic procedures and lack of clinician's dedication towards this health issue can lead to a missed diagnose. Herein, we present a case of a 51-year-old male, with a missed diagnosis of neurocysticercosis for more than two decades.

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Background: Connection between the duplication of the middle cerebral artery (DMCA) and the presence of multiple aneurysms has been described in a small number of cases.

Case Presentation: The presence of a rare type of DMCA associated with cerebral aneurysms was diagnosed in 56 year old woman after a rupture of an aneurysm on the dorsal segment of the DMCA. .

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Unlabelled: : Intracranial hemorrhage caused by the rupture of brain aneurysms occurs in almost 10 per 100,000 people whereas the incidence of such aneurysms is significantly higher, accounting for 4-9%.Linking certain factors to cerebral aneurysm rupture could help in explaining the significantly lower incidence of their rupture compared to their presence. The aim of this study is to determine the association between the corresponding circle of Willis configurations and rupture of cerebral aneurysms.

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Coherent optical communication systems are still too expensive for metro and short reach networks in the near future. Coherent detection with an intensity modulator replacing a costly dual-polarization in-phase and quadrature modulator could offer a good trade-off between cost and performance for metro networks. The major performance limit of such systems is the nonlinearity.

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Background: The risk factors implicated in the genesis of chronic subdural hematomas include old age, alcoholism, diabetes mellitus, arachnoid cysts, coagulopathy, anticoagulant (ACTh) and antiplatelet drugs. However, no study has reported an association between arterial hypertension (HTA) and chronic subdural hematomas. Therefore, the aim of this study was to investigate whether HTA is a risk factor for spontaneous chronic subdural hematomas (SCSDHs).

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We investigate partial response signaling (PRS) as a way of increasing the transmission length achievable by direct detection optical systems. The performance of the duobinary and PRS modulations is evaluated against that of conventional on-off-keying (OOK). We prove by simulation and experimentally that duobinary increases the link distance by up to 1.

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We experimentally demonstrate the generation and successful transmission of a single-lane 180 Gb/s (90 GBd) duo-binary four-level pulse-amplitude modulation (DB-PAM-4) signal over an 80 km standard single-mode fiber with a net data-rate of 150 Gb/s, enabled by a dual-drive Mach-Zehnder modulator-aided dispersion pre-compensation. A net data rate of 168 Gb/s is also achievable, for ranges up to 40 km. To mitigate bandwidth limitations and error spreading, pre-coded DB-PAM-4 is used; the pre-coding provides a gain of approximately 1 dB.

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We experimentally demonstrate the possibility of transmitting 112  Gb/s PAM-4 signals over 30-km standard single-mode fibers with commercial 20-GHz components. The impact on system performance of three different equalization schemes-feed-forward equalizer (FFE), Volterra filter (VF), and maximum likelihood sequence estimator (MLSE)-is investigated and compared. We prove that the |x| and x|x| components of the VF can efficiently reduce the chirp-induced signal skew distortion, and that an MLSE with only four states can be used to remove the error floor.

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Article Synopsis
  • Direct detection systems, particularly using PAM-4 modulation, are crucial for cost-effective and low-power metropolitan networks, but face challenges with transmission distance in the C-band.
  • Utilizing a dual drive Mach-Zehnder modulator allowed for the creation of a chromatic dispersion (CD) pre-compensated signal, achieving successful 128 Gbit/s transmission over an 80 km SSMF link.
  • This method represents the longest reach reported for single lane 100 Gbit/s PAM-4 signals in DCF-free links, enhanced by synchronized bandwidth pre-compensation to address bandwidth limitations.
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We experimentally demonstrate the generation and transmission of a single-lane 180  Gbit/s (90 GBaud) four-level pulse-amplitude modulation (PAM-4) signal in an intensity-modulation direct-detection system with a 7.5 GHz 3 dB bandwidth. The generated signal is transmitted over a 2 km standard single-mode fiber with, to the best of our knowledge, the highest reported net data rate in the C-band: 150  Gbit/s.

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Background/aim: Magnetic resonance imaging (MRI) is a key modality not only for lesion diagnosis, but also to evaluate the extension, type and grade of the tumor. Advanced MRI techniques provide physiologic information that complements the anatomic information available from conventional MRI. The aim of this study was to determine whether there is a correlation between apparent diffusion coefficient (ADC) maps of intracranial glial tumors and histopathologic findings and whether ADCs can reliably distinguish low-grade from high-grade gliomas.

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Introduction: Benign prostatic hyperplasia (BPH) causes disorders of voiding and sexual function. Phar- macologic therapy reduces symptoms of voiding thus impacting sexual function.

Objective: To determine sex life status in men with BPH before and after pharmacologic treatment adapted to achieve satisfactory sexual function.

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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is one of the most common hereditary forms of stroke, and migraine with aura, mood disorders and dementia. CADASIL is caused by mutations of the NOTCH3 gene. This mutation is inherited as an autosomal dominant trait.

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Introduction: Malignant Triton tumor is a very rare malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation. Most of those tumors occur in patients with von Recklinghausen's disease or as a late complication of irradiation and commonly seen in the head, neck, extremities and trunk.

Case Report: We reported retroperitoneal malignant Triton tumor in a 57-year-old female patient.

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Background: Renal onkocytoma is a distinctive benign tumor derived from epithelial cells of the distal renal tubules. These tumors are often clinically asymptomatic, diagnosed accidentally and difficult to distinguish from renal cell carcinoma.

Case Report: We presented a giant renal onkocytoma in a man aged 64, without any signs or symptoms of the urogenital system disorder.

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Background/aim: The presence of aneurysmal changes on the brain blood vessels has been subject to numerous research. This study investigated the relation between ruptured aneurysms and anatomical configuration of the Circle of Willis, with the purpose to obtain an insight into their mutual connection.

Methods: The analysis included 114 patients suffering from ruptured intracranial aneurysms.

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The prostatic adenocarcinoma is one of the most frequent malignant tumors of men over 50 years of age. It is distinguished by aggressive clinical course and heterogeneous multifocal histomorphologic changes. PSA is the most reliable serum marker in diagnostics and observation of prostatic carcinoma, and Gleason's system of tumor-diferentiation grading is generally accepted way of determining the histologic grade.

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