EFFECTS OF HIGH AND LOW DOSES OF ETHANOL, GIVEN TO RATS DURING THE PROCESS OF PREGNANCY, ON THE BEHAVIOR AND THE BLOOD RHEOLOGICAL PROPERTIES OF THEIR OFFSPRINGS.

In our experiments it has been established that during pregnancy the impact of ethanol high dose on rats' offspring induces a well pronounced increase of plasma viscosity, which is extremely important in blood circulation. The disruption of blood circulation causes a hypoxic condition (especially, in nervous tissues) and the disturbance of its functioning. This is the result of what has been seen in the behavioral experiments of female rats' offspring under the influence of ethanol high dose.

Antinociceptive tolerance to NSAIDs in the anterior cingulate cortex is mediated via endogenous opioid mechanism.

Background: In the past decade several studies have reported that in some brain areas, particularly, in the midbrain periaqueductal gray matter, rostral ventro-medial medulla, central nucleus of amygdala, nucleus raphe magnus, and dorsal hippocampus, microinjections of non-steroidal anti-inflammatory drugs (NSAIDs) induce antinociception with distinct development of tolerance. Given this evidence, in this study we investigated the development of tolerance to the analgesic effects of NSAIDs diclofenac, ketorolac and xefocam microinjected into the rostral part of anterior cingulate cortex (ACC) in rats.

Methods: Male Wistar experimental and control (saline) rats were implanted with a guide cannula in the ACC and tested for antinociception following microinjection of NSAIDs into the ACC in the tail-flick (TF) and hot plate (HP) tests.

Antinociceptive tolerance to NSAIDs in the agranular insular cortex is mediated by opioid mechanism.

Several lines of investigations have shown that in some brain areas, in particular, in the midbrain periaqueductal gray matter, rostral ventromedial medulla, central nucleus of amygdala, nucleus raphe magnus, and dorsal hippocampus, microinjections of nonsteroidal anti-inflammatory drugs (NSAIDs) induce antinociception with distinct development of tolerance. The agranular insular cortex (AIC) is a small region of the cerebral cortex located on the lateral area of the rat's cerebral hemisphere that is involved in the perception and response to pain. In the present study, we investigated the development of tolerance to the analgesic effects of NSAIDs diclofenac, ketorolac, and xefocam microinjected into the AIC in rats.

Antinociceptive tolerance to non-steroidal anti-inflammatory drugs microinjected into dorsal hippocampus of rats is due to pharmacological tolerance.

Pain is characterized as a complex experience, dependent not only on the regulation of nociceptive sensory systems, but also on the activation of mechanisms that control emotional processes in limbic brain areas such as the amygdala and the hippocampus. We have recently found that repeated microinjection of non-steroidal anti-inflammatory drugs (NSAIDs) into the dorsal hippocampus of rats for four consecutive days induces antinociceptive tolerance as revealed by a progressive decrease of the latency in the tail-flick and hot plate tests compared to controls treated with saline into the dorsal hippocampus. Here we found that on the first day microinjection of NSAIDs, ketorolac, clodifen and xefocam into the DH produced antinociception as revealed by a latency increase in the TF and HP compared to the baseline control of intact rats and a control group with saline microinjected into the same site as well.

Antinociceptive tolerance to NSAIDs microinjected into dorsal hippocampus.

Background: Pain is characterized as a complex experience, dependent not only on the regulation of nociceptive sensory systems, but also on the activation of mechanisms that control emotional processes in limbic brain areas such as the amygdala and the hippocampus. Several lines of investigations have shown that in some brain areas, particularly the midbrain periaqueductal gray matter, rostral ventro-medial medulla, central nucleus of amygdala and nucleus raphe magnus, microinjections of non-steroidal anti-inflammatory drugs (NSAIDs) induce antinociception with distinct development of tolerance. The present study was designed to examine whether microinjection of NSAIDs, clodifen, ketorolac and xefocam into the dorsal hippocampus (DH) leads to the development of antinociceptive tolerance in male rats.

[Efficiancy Angiotensin -converting enzyme inhibitors for the clinical practice].

These clinical trials show the efficiency of therapy with angiotensin-converting enzyme (ACE) inhibitors in essential hypertension (EH), chronic heart failure and coronary heart disease (CHD). The SMILE studies have indicated positive results of the early administration (<24 hours) of zofenopril in patients with acute myocardial infarction (AMI). These results have been confirmed in high-risk patients, including those with hypertension and diabetes mellitus, which enables zofenopril to be recommended for clinical use in patients with EH and CHD.

[Prevention of insult with nondirective anticoagulant therapy by warfarin (warfarex) in patients with atrial fibrillation].

The aim of the study was to estimate efficiency and safety of treatment by non-direct anticoagulant--warfarex in the patients with persistent and paroxysmal forms of AF for the prevention of thromboembolic complications. 55 patients between 37 and 75 years old with atrial fibrillation (AF) were investigated. Follow-up was 2 years.

[Clinical-hemodynamic and anti-ischemic effects ivabradine and nebivolol ischemic heart disease with left ventricular dysfunction].

The aim of this study was to examine the effectiveness of Ivabradine (available under the brandnames of Procoralan, Coralan, Corlentor, Coraxan, "Servier", France) and Nebivolol (Nebilet, "Berlin-Chemie", Germany) with combination of standard therapy in patients with coronary artery disease and left ventricular dysfunction. A total of 72 patients (mean age 57.3±4,5 years) have been observed during 6 months.

[The efficacy of propafenon in the case of supraventricular atrioventricular tachycardia].

One of the main methods the treatment of patients with supraventricular paroxysmal tachycardia remains drug therapy, which involves the prevention attacks of cardiac arrhythmias. Drugs of choice for termination and prevention of paroxysmal supraventricular tachycardia in the absence of pronounced signs structural myocardial damage is an antiarrhythmic with I C class (propafenon - propanorm). Efficacy of propafenon and its influence on the functional state of heart in patients with paroxysmal antrioventricular tachycardias was studied.

[The efficasy of atorvastatin in the case of paroxismal atrial fibrillation in patients with ischemic heart disease].

The purpose of the study was to estimate efficiency of atorvastatin in complex treatment with antiarhythmic drugs on the background of ischemic heart disease in patients with paroxysmal atrial fibrillation (AF). The investigation was conducted on 65 patients (37-72 years old) during 2 years. Two groups were composed.

Effect of morphine on the number and branching of astrocytes in various regions of rat brain.

We studied the effects of morphine in high doses on astrocytes in the nucleus accumbens, lateral septum, and caudate nucleus of rat brain. Activation of astrocytes in the nucleus accumbens and lateral septal nucleus was manifested in hyperplasia and elongation of astrocyte processes. In the caudate nucleus, the total length of astrocyte processes and branching of individual astrocytes decreased.

[The role of preparation LB in forming a thrombotic infarct of the cerebral cortex].

Non-invasion model for photochemically induced brain infarction was used to study the effect of a the new anti-ischemic drug LB ("Plaferon") in albino rats. Intensity of a local blood flow was measured so as oxygen tension in brain cortex. Square and volume of the disturbed nervous tissue region, capillary length and density of distribution of different caliber vessels were detected by means of light microscopy in serial sections of brain cortex.