Design, synthesis, molecular modelling and biological evaluation of novel 6-amino-5-cyano-2-thiopyrimidine derivatives as potent anticancer agents against leukemia and apoptotic inducers.

Herein, a novel series of 6-amino-5-cyano-2-thiopyrimidines and condensed pyrimidines analogues were prepared. All the synthesized compounds and were evaluated for anticancer activity by the National Cancer Institute (NCI; MD, USA) against 60 cell lines. Compound showed promising anticancer activity and was selected for the five-dose testing.